TH, tyrosine hydroxylase, 7054

N. diseases: 321; N. variants: 71
Disease: Schizophrenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 GeneticVariation disease BEFREE This study aimed to identify TH gene variants conferring risk for suicide attempt in schizophrenia while accounting for the interaction between this gene and clinical risk factors. 24275212 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 Biomarker disease BEFREE The present data suggest that the biosynthesis of catecholamine by the action of TH should be deeply involved in decreased intellectual ability in patients with schizophrenia. 24417771 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 AlteredExpression disease BEFREE The combined schizophrenia group had higher TH and GAD67 protein levels than controls (an increase of 69.6%, P=0.01 and 19.5%, P=0.004, respectively). 27550734 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 AlteredExpression disease BEFREE TH and aromatic acid decarboxylase (AADC) mRNA and TH protein were unchanged in the midbrain in schizophrenia compared with controls. 28094812 2017