TIMP3, TIMP metallopeptidase inhibitor 3, 7078

N. diseases: 325; N. variants: 19
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.070 Biomarker group BEFREE In contrast, expression levels of MMP-1, MMP-8, MMP-9 and TIMP-3 are higher in SQ than in AD. 22292754 2012
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.070 Biomarker group BEFREE Methylation rates for ID4, DCL1, BNIP3, H2AFX, CACNA1G and TIMP3 were significantly different between squamous and adenocarcinomas. 20849603 2010
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.070 PosttranslationalModification group LHGDN In summary, we observed frequent TIMP-3 promoter methylation in adenocarcinomas of the esophagus and stomach and the loss of TIMP-3 expression seems to be of clinical and prognostic relevance in these cancers. 18516293 2008
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.070 PosttranslationalModification group BEFREE In summary, we observed frequent TIMP-3 promoter methylation in adenocarcinomas of the esophagus and stomach and the loss of TIMP-3 expression seems to be of clinical and prognostic relevance in these cancers. 18516293 2008
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.070 PosttranslationalModification group BEFREE The promoter methylation of TIMP-3 was significantly higher in adenocarcinoma than in squamous cell carcinoma (41.7% vs 3%, respectively, P= 0.0175). 16803511 2007
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.070 Biomarker group LHGDN TIMP3 seems to play an important role in the tumorigenesis of primary pancreatic adenocarcinomas. 15714128 2005
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.070 AlteredExpression group LHGDN Tissue inhibitor of metalloproteinase-3 (TIMP-3) gene is methylated in the development of esophageal adenocarcinoma: loss of expression correlates with poor prognosis. 15688381 2005
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.070 Biomarker group BEFREE TIMP3 seems to play an important role in the tumorigenesis of primary pancreatic adenocarcinomas. 15714128 2005
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.070 AlteredExpression group BEFREE Localization of MT1-MMP, TIMP-1, TIMP-2, and TIMP-3 messenger RNA in normal, hyperplastic, and neoplastic endometrium. Enhanced expression by endometrial adenocarcinomas is associated with low differentiation. 10989641 2000