C1QBP, complement C1q binding protein, 708

N. diseases: 111; N. variants: 9
Disease: Endothelial dysfunction ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.010 Biomarker phenotype BEFREE Arginase activity, p32 protein expression, spermine amount, and [Ca<sup>2+</sup>]m were increased in the aortas from apolipoprotein E (ApoE<sup>-/-</sup>) mice fed a high-cholesterol diet, and intravenous administration of small interfering RNA against p32 restored Ca<sup>2+</sup>/Ca<sup>2+</sup>/calmodulin-dependent kinase II -dependent eNOS Ser1177 phosphorylation and improved endothelial dysfunction. 30371203 2018