Chronic Obstructive Airway Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
These effects may be related to the regulation of TLR2/4 and might lead to modulation of inflammation with possible deleterious consequences for COPD patients.
|
30268700 |
2019 |
Chronic Obstructive Airway Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, we show that TLR2 is required for limiting RV-induced IFNs, and this pathway is dysregulated in COPD airway epithelial cells, leading to exaggerated IFN production.
|
31548332 |
2019 |
Chronic Obstructive Airway Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
What is the main finding and its importance? eHsp70 modulates inflammatory responses and TLR2, TLR4 and Hsp70 gene expression, and protects NCI-H292 cells against CSE-induced cytotoxicity. eHsp70 might be implicated in development of inflammatory diseases affected by cigarette smoke, such as COPD.
|
30298576 |
2018 |
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We stimulated alveolar macrophages from COPD patients (n=9) and smokers (n=8) with the TLR4 agonist lipopolysaccharide (LPS) or the TLR2 agonist Pam3CSK4 for 24 hours before restimulating again for 24 hours.
|
29535517 |
2018 |
Chronic Obstructive Airway Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TLR2, TLR4, and associated coreceptor mRNA expression was increased in the airways in both experimental and human COPD.
|
29025711 |
2018 |
Chronic Obstructive Airway Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, HMGB1 is responsible for A. fumigatus-induced inflammatory response in COPD alveolar macrophage via Dectin-1 and TLR2/4 receptor through activating MyD88/NF-κB and syk/PI3K signalings.
|
29078091 |
2017 |
Chronic Obstructive Airway Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our objective here was to investigate TLR and NLR signalling pathways in the bronchial mucosa in stable COPD.Using immunohistochemistry, the expression levels of TLR2, TLR4, TLR9, NOD1, NOD2, CD14, myeloid differentiation primary response gene 88 (MyD88), Toll-interleukin-1 receptor domain-containing adaptor protein (TIRAP), and the interleukin-1 receptor-associated kinases phospho-IRAK1 and IRAK4 were measured in the bronchial mucosa of subjects with stable COPD of different severity (n=34), control smokers (n=12) and nonsmokers (n=12).
|
28536249 |
2017 |
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that specific TLR polymorphisms are associated with dysfunctional innate immune COPD alveolar macrophage responses and investigated polymorphisms of TLR2(Arg753Gln), TLR4(Thr399Ile; Asp299Gly), and TLR9(T1486C; T1237C).
|
26361369 |
2015 |
Chronic Obstructive Airway Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
COPD and control alveolar macrophages were exposed to cigarette smoke extract (CSE) followed by TLR-2, -4 and -5 ligands [Pam3CSK4, lipopolysaccharide (LPS) and phase I flagellin (FliC), respectively] or non-typeable Haemophilus influenzae (NTHi).
|
24528166 |
2014 |
Chronic Obstructive Airway Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TLR2 levels were increased with ageing, while sputum neutrophils and total sputum MMP-9 levels increased with age, previous smoking, and COPD.
|
23606791 |
2013 |
Chronic Obstructive Airway Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This is the first longitudinal study showing that tagging SNPs in TLR2 and TLR4 are associated with the level and decline of lung function as well as with inflammatory cell numbers in induced sputum in COPD patients, suggesting a role in the severity and progression of COPD.
|
22952638 |
2012 |
Chronic Obstructive Airway Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Decreased Toll-like receptor 2 (TLR2) expression has been reported in patients with chronic obstructive pulmonary disease and in a murine asthma model, which may predispose the hosts to bacterial infections, leading to disease exacerbations.
|
21239529 |
2011 |
Chronic Obstructive Airway Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of TLR2 was lower on sputum neutrophils and soluble TLR2 (sTLR2) was higher in the supernatant in the COPD group, indicating a down regulation of TLR2 at the transit from blood to sputum.
|
21439805 |
2011 |
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to investigate whether there is a link between polymorphisms in TLR2 and the onset or course of COPD.
|
19381722 |
2009 |
Chronic Obstructive Airway Disease
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Upon stimulation with TLR-2 ligand monocytes from COPD patients secreted increased amounts of cytokines than similarly stimulated monocytes from never smokers and smokers.
|
16606450 |
2006 |
Chronic Obstructive Airway Disease
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
The expression of TLR2, TLR4 and CD14 on AM from COPD patients, smokers and non-smokers was reduced as compared to autologous monocytes.
|
16004610 |
2005 |