TLR4, toll like receptor 4, 7099

N. diseases: 1174; N. variants: 54
Disease: Cytokine storm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0919747
Disease: Cytokine storm
Cytokine storm 		0.030 Biomarker disease BEFREE Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization. 31412243 2019
CUI: C0919747
Disease: Cytokine storm
Cytokine storm 		0.030 Biomarker disease BEFREE Therefore, FP7 can antagonize TLR4 activation in vitro and protect mice from severe influenza infection, most likely by reducing TLR4-dependent cytokine storm mediated by damage-associated molecular patterns (DAMPs) like HMGB1. 28106157 2017
CUI: C0919747
Disease: Cytokine storm
Cytokine storm 		0.030 Biomarker disease BEFREE We showed that CD300b, and its adaptor DAP12, associated with Toll-like receptor 4 (TLR4) upon LPS binding, thereby enhancing TLR4-adaptor MyD88- and TRIF-dependent signaling that resulted in an elevated pro-inflammatory cytokine storm. 27261276 2016