Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
From the above results, we conclude that LAP2 is widely overexpressed in diverse digestive tract cancers and LAP2β regulates motility of cancer cells and suggest that LAP2β may have utility for diagnostics and therapeutics in digestive tract cancers.
|
22745766 |
2012 |
Carcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Neither the normal nor the benign lesions of the breast showed positive TMPO immunodetection, whilst 45 % of the breast carcinomas were immunopositive (p = 0.000), nine of ten positives carcinomas correspond to the Luminal A subtype.
|
25837847 |
2015 |
Carcinoma, Papillary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In papillary carcinomas (PCs), the nuclear proteins most frequently expressed at high levels were emerin (82 % positive), lamin A/C (64 %), and LAP2 (82 %).
|
26254781 |
2015 |
Esophageal Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells.
|
24589738 |
2014 |
Fetal Growth Retardation
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Together our data indicate that expression of TPα mediates normal placentation; however, TPβ impairs placentation, and promotes the development of IUGR, and represents an underappreciated pathogenic factor in humans.
|
27363493 |
2016 |
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study observed that the expression of TMPO in GBM specimens was remarkably higher than that in normal brain specimens.
|
27756319 |
2016 |
Herpes Simplex Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
We examined the ability of the herpes simplex virus (HSV) latency-associated promoter (LAP2) to drive biologically relevant prolonged transgene expression in the peripheral nervous system.
|
15927533 |
2005 |
Lung Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Collectively, NNK promotes lung tumor growth via inducing TxAS and TPα, which constitutes an auto-positive feedback loop to exaggerate the growth.
|
24115277 |
2013 |
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry showed that the expression of TMPO-α was significantly higher in GC tissues and cells in comparison with non-tumor tissues and cells.
|
31602262 |
2019 |
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, the overexpression of TMPO-α in gastric tissues (56%) was positively associated with Lauren classification (<i>P</i> = 0.0159), nodal status (<i>P</i> = 0.0265), distant metastasis (<i>P</i> < 0.0001), stage (<i>P</i> = 0.0367), and degree of differentiation (<i>P</i> = 0.0009).
|
31602262 |
2019 |
prostatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Differential expression of the TPα and TPβ isoforms of the human T Prostanoid receptor during chronic inflammation of the prostate: Role for FOXP1 in the transcriptional regulation of TPβ during monocyte-macrophage differentiation.
|
31271729 |
2019 |
Esophageal carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells.
|
24589738 |
2014 |
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The upregulation of TMPO-AS1, TMPO mRNA and protein levels were associated with tumor progression of NSCLC.
|
31230752 |
2019 |
Fibroadenoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TMPO expression was analyzed by immunohistochemistry in tissue microarray containing 46 breast tissue samples including normal (n = 6), benign lesions (n = 18) (fibroadenomas (n = 6), fibrocystic changes (n = 6), ductal hyperplasias (n = 6)) and breast carcinoma (n = 22).
|
25837847 |
2015 |
Medullary carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In all medullary carcinomas (MCs), intermediate to high levels of expression of lamin A/C and LAP2 were found.
|
26254781 |
2015 |
Carcinoma, Large Cell
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Using immunohistochemistry with antibodies for emerin, lamin A/C, lamin B, and LAP2, we examined 105 lung cancer tissues from 33 small cell lung carcinomas (SCLCs) and 72 non-SCLCs (34 adenocarcinomas, 30 squamous cell carcinomas, and 8 large cell carcinomas).
|
31201505 |
2019 |
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Depletion of thymopoietin inhibits proliferation and induces cell cycle arrest/apoptosis in glioblastoma cells.
|
27756319 |
2016 |
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Depletion of thymopoietin inhibits proliferation and induces cell cycle arrest/apoptosis in glioblastoma cells.
|
27756319 |
2016 |
Non-alcoholic Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease.
|
28902428 |
2018 |
Neuropathy
|
0.010 |
Biomarker
|
group |
BEFREE |
These results indicate that expression of NGF or NT-3 driven by LAP2 is sufficient to prevent the development of neuropathy 6 months after vector inoculation in rats.
|
15927533 |
2005 |
Malignant neoplasm of esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells.
|
24589738 |
2014 |
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
According with the present data, we suggest that TMPOβ and -γ isoforms could provide a potential reliable diagnostic marker for breast cancer.
|
25837847 |
2015 |
Stomach Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry showed that the expression of TMPO-α was significantly higher in GC tissues and cells in comparison with non-tumor tissues and cells.
|
31602262 |
2019 |
Bile duct carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry in patient tissues showed widespread expression of LAP2 in diverse digestive tract cancers including stomach, pancreas, liver, and bile duct cancers.
|
22745766 |
2012 |
Cardiomyopathies
|
0.010 |
Biomarker
|
group |
BEFREE |
To test this, we analyzed RNA-Seq datasets, finding novel isoforms or isoform tissue-specificity for: Lap2, linked to cardiomyopathy; Nesprin 2, linked to Emery-Dreifuss muscular dystrophy and Lmo7, that regulates the Emery-Dreifuss muscular dystrophy linked emerin gene.
|
29912636 |
2018 |