TMPO, thymopoietin, 7112

N. diseases: 58; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.010 AlteredExpression group BEFREE From the above results, we conclude that LAP2 is widely overexpressed in diverse digestive tract cancers and LAP2β regulates motility of cancer cells and suggest that LAP2β may have utility for diagnostics and therapeutics in digestive tract cancers. 22745766 2012
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.010 Biomarker group BEFREE Neither the normal nor the benign lesions of the breast showed positive TMPO immunodetection, whilst 45 % of the breast carcinomas were immunopositive (p = 0.000), nine of ten positives carcinomas correspond to the Luminal A subtype. 25837847 2015
CUI: C0007133
Disease: Carcinoma, Papillary
Carcinoma, Papillary
0.010 AlteredExpression disease BEFREE In papillary carcinomas (PCs), the nuclear proteins most frequently expressed at high levels were emerin (82 % positive), lamin A/C (64 %), and LAP2 (82 %). 26254781 2015
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms
0.010 AlteredExpression group BEFREE Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells. 24589738 2014
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation
0.010 AlteredExpression phenotype BEFREE Together our data indicate that expression of TPα mediates normal placentation; however, TPβ impairs placentation, and promotes the development of IUGR, and represents an underappreciated pathogenic factor in humans. 27363493 2016
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.010 AlteredExpression disease BEFREE This study observed that the expression of TMPO in GBM specimens was remarkably higher than that in normal brain specimens. 27756319 2016
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.010 Biomarker group BEFREE We examined the ability of the herpes simplex virus (HSV) latency-associated promoter (LAP2) to drive biologically relevant prolonged transgene expression in the peripheral nervous system. 15927533 2005
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.010 Biomarker group BEFREE Collectively, NNK promotes lung tumor growth via inducing TxAS and TPα, which constitutes an auto-positive feedback loop to exaggerate the growth. 24115277 2013
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.010 AlteredExpression disease BEFREE Immunohistochemistry showed that the expression of TMPO-α was significantly higher in GC tissues and cells in comparison with non-tumor tissues and cells. 31602262 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 AlteredExpression phenotype BEFREE Furthermore, the overexpression of TMPO-α in gastric tissues (56%) was positively associated with Lauren classification (<i>P</i> = 0.0159), nodal status (<i>P</i> = 0.0265), distant metastasis (<i>P</i> < 0.0001), stage (<i>P</i> = 0.0367), and degree of differentiation (<i>P</i> = 0.0009). 31602262 2019
CUI: C0033581
Disease: prostatitis
prostatitis
0.010 AlteredExpression disease BEFREE Differential expression of the TPα and TPβ isoforms of the human T Prostanoid receptor during chronic inflammation of the prostate: Role for FOXP1 in the transcriptional regulation of TPβ during monocyte-macrophage differentiation. 31271729 2019
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma
0.010 AlteredExpression disease BEFREE Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells. 24589738 2014
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.010 AlteredExpression phenotype BEFREE The upregulation of TMPO-AS1, TMPO mRNA and protein levels were associated with tumor progression of NSCLC. 31230752 2019
CUI: C0206650
Disease: Fibroadenoma
Fibroadenoma
0.010 AlteredExpression disease BEFREE TMPO expression was analyzed by immunohistochemistry in tissue microarray containing 46 breast tissue samples including normal (n = 6), benign lesions (n = 18) (fibroadenomas (n = 6), fibrocystic changes (n = 6), ductal hyperplasias (n = 6)) and breast carcinoma (n = 22). 25837847 2015
CUI: C0206693
Disease: Medullary carcinoma
Medullary carcinoma
0.010 AlteredExpression disease BEFREE In all medullary carcinomas (MCs), intermediate to high levels of expression of lamin A/C and LAP2 were found. 26254781 2015
CUI: C0206704
Disease: Carcinoma, Large Cell
Carcinoma, Large Cell
0.010 GeneticVariation disease BEFREE Using immunohistochemistry with antibodies for emerin, lamin A/C, lamin B, and LAP2, we examined 105 lung cancer tissues from 33 small cell lung carcinomas (SCLCs) and 72 non-SCLCs (34 adenocarcinomas, 30 squamous cell carcinomas, and 8 large cell carcinomas). 31201505 2019
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.010 Biomarker disease BEFREE Depletion of thymopoietin inhibits proliferation and induces cell cycle arrest/apoptosis in glioblastoma cells. 27756319 2016
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.010 Biomarker disease BEFREE Depletion of thymopoietin inhibits proliferation and induces cell cycle arrest/apoptosis in glioblastoma cells. 27756319 2016
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease
0.010 Biomarker disease BEFREE Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease. 28902428 2018
CUI: C0442874
Disease: Neuropathy
Neuropathy
0.010 Biomarker group BEFREE These results indicate that expression of NGF or NT-3 driven by LAP2 is sufficient to prevent the development of neuropathy 6 months after vector inoculation in rats. 15927533 2005
CUI: C0546837
Disease: Malignant neoplasm of esophagus
Malignant neoplasm of esophagus
0.010 AlteredExpression disease BEFREE Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells. 24589738 2014
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.010 Biomarker disease BEFREE According with the present data, we suggest that TMPOβ and -γ isoforms could provide a potential reliable diagnostic marker for breast cancer. 25837847 2015
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.010 AlteredExpression disease BEFREE Immunohistochemistry showed that the expression of TMPO-α was significantly higher in GC tissues and cells in comparison with non-tumor tissues and cells. 31602262 2019
CUI: C0740277
Disease: Bile duct carcinoma
Bile duct carcinoma
0.010 AlteredExpression disease BEFREE Immunohistochemistry in patient tissues showed widespread expression of LAP2 in diverse digestive tract cancers including stomach, pancreas, liver, and bile duct cancers. 22745766 2012
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies
0.010 Biomarker group BEFREE To test this, we analyzed RNA-Seq datasets, finding novel isoforms or isoform tissue-specificity for: Lap2, linked to cardiomyopathy; Nesprin 2, linked to Emery-Dreifuss muscular dystrophy and Lmo7, that regulates the Emery-Dreifuss muscular dystrophy linked emerin gene. 29912636 2018