CLDN5, claudin 5, 7122

N. diseases: 104; N. variants: 2
Disease: Schizophrenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease BEFREE At the blood-brain barrier, claudin-5 is the most enriched tight junction protein and its dysfunction has been implicated in neurodegenerative disorders such as Alzheimer's disease, neuroinflammatory disorders such as multiple sclerosis as well as psychiatric disorders including depression and schizophrenia. 30691500 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease BEFREE However, although there is no common mechanism underpinning BBB dysfunction even within each particular disorder, the tight junction protein claudin-5 may be a clinically relevant target given that both clinical and pre-clinical research has linked it to schizophrenia, ASD, and depression. 29966749 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 AlteredExpression disease BEFREE Here, we show that a variant in the claudin-5 gene is weakly associated with schizophrenia in 22q11DS, leading to 75% less claudin-5 being expressed in endothelial cells. 28993710 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease BEFREE Here, we focus on the endothelial tight-junction protein claudin-5 (CLDN5), because the <i>CLDN5</i> gene is mapped to the schizophrenia-associated 22q11.2 deletion region, and a single nucleotide polymorphism in the <i>CLDN5</i> locus is also linked to schizophrenia. 29212157 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease BEFREE CLDN-5 protein was increased in ASD cortex and cerebellum, while CLDN-12 appeared reduced in both ASD and SCZ cortexes. 27957319 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease LHGDN Further study of a genetic association between the CLDN5 locus and schizophrenia. 15820333 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease PSYGENET The present results suggest that the PLA2G4A locus may be involved in schizophrenia and its combination with the CLDN5 gene may increase further the risk for the illness. 16181776 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease LHGDN Gene, gut and schizophrenia: the meeting point for the gene-environment interaction in developing schizophrenia. 15617864 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE The present results suggest that the PLA2G4A locus may be involved in schizophrenia and its combination with the CLDN5 gene may increase further the risk for the illness. 16181776 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease LHGDN Because the claudin proteins are a major component for barrier-forming tight junctions that could play a crucial role in response to changing natural, physiological and pathological conditions, the CLDN5 association with schizophrenia may be an important clue leading to look into a meeting point of genetic and environmental factors. 15363474 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease PSYGENET Because the claudin proteins are a major component for barrier-forming tight junctions that could play a crucial role in response to changing natural, physiological and pathological conditions, the CLDN5 association with schizophrenia may be an important clue leading to look into a meeting point of genetic and environmental factors. 15363474 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease BEFREE Because the claudin proteins are a major component for barrier-forming tight junctions that could play a crucial role in response to changing natural, physiological and pathological conditions, the CLDN5 association with schizophrenia may be an important clue leading to look into a meeting point of genetic and environmental factors. 15363474 2004