|
Scheuermann's Disease
|
0.200 |
Biomarker
|
disease |
MGD |
Mice with a targeted deletion of the tetranectin gene exhibit a spinal deformity.
|
11604516 |
2001 |
|
Serum albumin measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
|
22286219 |
2012 |
|
Neoplasm Metastasis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Downregulation of exosomal CLEC3B in hepatocellular carcinoma promotes metastasis and angiogenesis via AMPK and VEGF signals.
|
31477130 |
2019 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
The CLEC3B gene encodes tetranectin, a protein implicated in the mineralization process in osteogenesis as well as in the prognosis and metastasis of cancer.
|
27154906 |
2017 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
In malignancies, tetranectin is thought to enhance proteolytic processes enabling tumor cells to invade and metastasize.
|
29151948 |
2017 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Since tetranectin binds to plasminogen we hypothesize that it could function as an anchor and/or reservoir for plasminogen and similar substances that regulate tumor invasion and metastasis as well as tumor angiogenesis.
|
1354271 |
1992 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
CLEC3B secreted from CAFs may promote tumour migration.
|
30894065 |
2019 |
|
Liver carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to compare external radiation (beam radiation) and internal radiation as a single radiation therapy to advanced HCC patients (TNA stage III and IV according to the derived AJCC Stage, 6th edition) stratified by other risk factors, based on the data collected from the Surveillance, Epidemiology and End Results (SEER) national database.
|
30854126 |
2019 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Exosomes derived from HCC with down-regulated CLEC3B promoted migration, invasion, epithelial-mesenchymal transition of both tumor cells and endothelial cells (ECs).
|
31477130 |
2019 |
|
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
In conclusion, TMEM88, CCL14, and CLEC3B genes were stable and available in predicting the survival and palindromia time of hepatocellular carcinoma.
|
28718365 |
2017 |
|
Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Multivariate Cox regression analysis restricted to 107 OC patients with a p53 missense mutation or p53 wild type in the tumor tissue and with information on radicality of primary surgery showed that missense p53 mutation (HR = 2.5, 95% CI: 1.21-4.98), radicality after primary surgery (HR = 1.7, 95% CI: 1.04-2.88), tetranectin (mg/l: HR = 0.78, 95% CI: 0.67-0.91) and stage (I vs. III: HR = 0.30, 95% CI: 0.10-0.92, II vs. III: HR = 0.24, 95% CI: 0.05-1.05, IV vs. III: HR = 2.70, 95% CI: 1.22-5.98) were independent prognostic factors.
|
16183105 |
2006 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Immunohistochemically, tetranectin was found in a fibrillar-like pattern in the extracellular matrix around the tumor islands and was not detectable in the normal colon stromal tissue.
|
1354271 |
1992 |
|
Tumor Progression
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The function of exosomal CLEC3B in tumor progression were performed in vivo and in vitro.
|
31477130 |
2019 |
|
Tumor Progression
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
The downregulation of CLEC3B was associated with tumor progression and predicted unfavorable prognostic outcomes in the TCGA cohort.
|
30066941 |
2018 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
High intratumoral tetranectin level was positively associated with tumor invasion (P = 0.013), lymph node metastasis (P = 0.005), advanced TNM stage (P = 0.003) and shorter overall survival (OS) (P < 0.001) for patients with gastric cancer.
|
29151948 |
2017 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Since tetranectin binds to plasminogen we hypothesize that it could function as an anchor and/or reservoir for plasminogen and similar substances that regulate tumor invasion and metastasis as well as tumor angiogenesis.
|
1354271 |
1992 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry revealed that CLEC3B expression was associated with serosal invasion by CRC.
|
30894065 |
2019 |
|
nervous system disorder
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Although our findings do not support an association between CLEC3B p.S106G and aging without neurological disease (P=0.89), we confirmed the association between the APOE ε2 allele and better survival without neurological disease (P=0.001).
|
31570938 |
2019 |
|
Secondary malignant neoplasm of bone
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CD59 and haptoglobin were up-regulated in prostate cancer with bone metastasis while tetranectin was down-regulated.
|
31413735 |
2019 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
It has been verified that CD59, haptoglobin and tetranectin are prostate cancer bone metastasis related proteins.
|
31413735 |
2019 |
|
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
It has been verified that CD59, haptoglobin and tetranectin are prostate cancer bone metastasis related proteins.
|
31413735 |
2019 |
|
Kyphosis deformity of spine
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Serum TN level is proved to be related to the efficiency of posterior spinal V osteotomy in patients with traumatic kyphosis, and may serve as a possible indicator for clinical treatment.
|
29384840 |
2018 |
|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
In summary, tetranectin and titin in plasma appeared to be closely associated with the onset of AMI among T2DM patients and can be used as potential biomarkers for prediction of a cardiac event, though this requires validation in a prospective cohort study.
|
29417940 |
2018 |
|
Congenital kyphosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Serum TN level is proved to be related to the efficiency of posterior spinal V osteotomy in patients with traumatic kyphosis, and may serve as a possible indicator for clinical treatment.
|
29384840 |
2018 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
CLEC3B demonstrated substantial positive associations with proliferation inhibitors, but inverse associations with proliferation inducers and markers in two large ccRCC cohorts, suggesting that CLEC3B was able to identify ccRCCs with a lower proliferation capacity.
|
30066941 |
2018 |