|
HIV Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our findings indicate significant association of pro-inflammatory (IL2, IFN-γ, TNF-α) and anti-inflammatory cytokine gene variants (IL4, IL10) with the risk to acquire the HIV infection and development of AIDS related illness in Indian population.
|
31173933 |
2019 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
We observed several distinct biomarker pathways induced following HIV infection such as IFN-γ-signaled chemokines, proinflammatory markers, and TNF-α-family members.
|
29769442 |
2018 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
The results showed significant impact of aging on all five biomediators and that of HIV infection on all but sTNFR-1.
|
29097998 |
2017 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
This study suggests that the rate of serious infections in patients with HIV infection under active care who have received treatment with TNF inhibitors may be comparable to the rates observed in registry databases.
|
27332039 |
2017 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
The relationship between TNF-α and HIV infection, as well as cautionary guidelines regarding the utilization of anti-TNF therapy in this clinical population, is discussed.
|
28255643 |
2017 |
|
HIV Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Results also suggested increased IL-1β, IFN-γ, TNF, and RANTES (CCR5) activity upstream of the central memory CD4 T cells signature, consistent with the demonstrated milieu in HIV infection.
|
27875993 |
2016 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
In contrast, monocytes from hosts of pathogenic infections (HIV-infected humans and SIV-infected Asian macaques) maintained a robust TNF-α response.
|
22553338 |
2012 |
|
HIV Infections
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Increased erythrocyte glutathione peroxidase activity and serum tumor necrosis factor-alpha in HIV-infected patients: relationship to on-going prothrombotic state.
|
11983108 |
2002 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
HIV infection and aging: enhanced Interferon- and Tumor Necrosis Factor-alpha production by the CD8+ CD28- T subset.
|
11696237 |
2001 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, our findings suggest that HIV infection of astrocytic cells can contribute to the establishment of a chronic inflammatory state in the CNS, eventually resulting in HIV encephalitis, by increasing the secretion of pro-inflammatory cytokines, such as TNF-alpha and several chemokines.
|
10786999 |
2000 |
|
HIV Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The 8.1 major histocompatibility complex (MHC) ancestral haplotype (HLA-A1,B8,TNFA-308(2),DR3) is associated with elevated TNF production and predisposes carriers to several autoimmune/immunopathological disorders, including rapid progression of HIV disease, but not early onset periodontal disease in healthy individuals.
|
10551423 |
1999 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, we analysed the regulation of B7 expression by cytokines, namely IL-10 and tumour necrosis factor-alpha (TNF-alpha), the production of which is enhanced in HIV infection and have similar inhibitory effects on B7 expression.
|
10403920 |
1999 |
|
HIV Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our results serve to highlight the potential importance of genetic polymorphism, particularly of the TNF locus, in influencing the progression of HIV infection.
|
9084788 |
1997 |
|
HIV Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Thus, the spontaneous production of IL-6 and TNF-alpha by B cells from individuals infected with HIV may contribute to viral expression as well as to the hypergammaglobulinemia often associated with HIV infection.
|
1376041 |
1992 |