|
Mycobacterium Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
We found that glibenclamide significantly reduced M1 (HLA-DR<sup>+</sup> and CD86<sup>+</sup>) surface markers and TNF-α production on primary human monocytes against mycobacterial infection.
|
30283449 |
2018 |
|
Mycobacterium Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Understanding the immunopathogenesis of CD is crucial, since using TNFα inhibitors in these patients could favor mycobacterial infections, particularly <i>Mycobacterium avium</i> subspecies <i>paratuberculosis</i>, which ultimately could worsen their clinical condition.
|
29991880 |
2018 |
|
Mycobacterium Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Major cytokines like TNFα exert a multifold role in host control of mycobacterial infections.
|
29872095 |
2018 |
|
Mycobacterium Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
TNF-α is a critical host-protective cytokine against mycobacterial diseases.
|
29712918 |
2018 |
|
Mycobacterium Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, we aimed to investigate the prevalence of several polymorphisms within innate immune response genes related to susceptibility to mycobacterial diseases (in SLC11A1, MBL2, TLR2, P2RX7, IL10, TNFA) in time series data from North and East Poland (1st-18th century AD, n = 207).
|
29763671 |
2018 |
|
Mycobacterium Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Mycobacterial diseases are prevalent in cancer and rheumatoid arthritis (RA) patients, especially those receiving tumor necrosis factor-α inhibitor (TNFi).
|
28737121 |
2017 |
|
Mycobacterium Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Significant associations between mycobacterial infection and TNF-α production after stimulating peripheral blood mononuclear cells with LPS alone and with IFN-γ plus LPS were identified.
|
27686649 |
2016 |
|
Mycobacterium Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Administration of TNF-neutralizing biologics disrupted the control of mycobacterial infection in huTNF KI mice, leading to an increased bacterial burden and hyperinflammation.
|
26123801 |
2015 |
|
Mycobacterium Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
We highlight granuloma heterogeneity that emerges in the context of infection, the functional consequences of angiogenesis in tuberculous granulomas, and data that balanced inflammation in humans, with a central role for tumor necrosis factor, appears to play a key role in optimal defense against mycobacterial infection.
|
25703566 |
2015 |
|
Mycobacterium Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
TNF-α modulates TLR2-dependent responses during mycobacterial infection.
|
24788179 |
2014 |
|
Mycobacterium Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
To determine mechanisms for MIF's protective role, we studied both aerosolized and i.v. models of mycobacterial infection and observed MIF-deficient mice to succumb more quickly with higher organism burden, increased lung pathology, and decreased innate cytokine production (TNF-α, IL-12, IL-10).
|
23882081 |
2013 |
|
Mycobacterium Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
This report expands our knowledge about tumor necrosis factor superfamily members involved in the immune responses to mycobacterial infection by identifying CD30-CD153 interactions as required for optimal immune control of M. avium infection.
|
15316035 |
2004 |
|
Mycobacterium Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
However, there is a growing body of clinical evidence that neutralization of TNF-alpha is associated with an increased risk of opportunistic infections, including mycobacterial diseases.
|
12763679 |
2003 |
|
Mycobacterium Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
The antibody to TNF-alpha inhibited CAT production induced by mycobacterial infections.
|
11549416 |
2001 |
|
Mycobacterium Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha released from alveolar macrophages (AM) in pulmonary tuberculosis (TB) are important in host defense against mycobacterial infection.
|
10619820 |
2000 |
|
Mycobacterium Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Four children with severe mycobacterial infections had a mutation in the gene for interferon-gamma receptor 1 that leads to the absence of receptors on cell surfaces and a functional defect in the up-regulation of tumor necrosis factor alpha by macrophages in response to interferon-gamma.
|
8960473 |
1996 |
|
Mycobacterium Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
TNF and IFN-gamma are thought to be involved in the immune response to mycobacterial infection because they exhibit antimycobacterial effects in vitro.
|
2113553 |
1990 |