TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Disease: Abnormality of limbs ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1387925
Disease: Abnormality of limbs
Abnormality of limbs 		0.010 GeneticVariation phenotype BEFREE Increased risk of limb anomaly was observed for three SNPs: heterozygosity for F5 Arg506Gln, with an odds ratio (OR) of 2.5 (95% confidence interval (CI), 1.0, 6.5); heterozygosity for TNF (-376)G > A, OR 2.1 (0.7, 6.2); and homozygosity for NPPA 2238T > C, OR 4.0 (1.1, 15.4). 17036337 2006