Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Keratinocyte Expression of A20/TNFAIP3 Controls Skin Inflammation Associated with Atopic Dermatitis and Psoriasis.
|
30118730 |
2019 |
Psoriasis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Moreover, a significant negative correlation was found between TNFAIP3 mRNA in psoriatic tissue and psoriasis area severity index values (rs = -0.382, P-value = 0.037).
|
31120955 |
2019 |
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in CD84, IL12B and TNFAIP3 are associated with response to biologics in patients with psoriasis.
|
27564082 |
2017 |
Psoriasis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Examination of TNFAIP3 mRNA expression in skin biopsies from patients with psoriasis revealed reduced expression in both involved and uninvolved skin.
|
28658319 |
2017 |
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The association between tumor necrosis factor-alpha induced protein 3 interacting protein 1 (TNIP1) gene and psoriasis was confirmed in people with multiple ethnicities.
|
27364786 |
2016 |
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In addition, there are numerous other genetic susceptibility loci (LCE3, CARD14, NOS2, NFKBIA, PSMA6, ERAP1, TRAF3IP2, IL12RB2, IL23R, IL12B, TNIP1, TNFAIP3, TYK2) and geoepidemiologic factors that contribute to the wide variability seen in psoriasis.
|
26780035 |
2016 |
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.
|
26626624 |
2015 |
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.
|
25903422 |
2015 |
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies in white and Chinese Han populations have found that the single-nucleotide polymorphism (SNP) rs610604, at the tumour necrosis factor (TNF)-α-induced protein 3 (TNFAIP3) locus, is associated with psoriasis, and is also associated with response to TNF blockade in psoriasis.
|
25496073 |
2015 |
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The TNFAIP3 gene is involved in the TNF-α signalling cascade (P-value: 0.004952), a key step in the pathogenesis of psoriasis.
|
25406098 |
2015 |
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Among identified psoriasis risk variants, three were more strongly associated with PsC than PsA (rs12189871 near HLA-C, p = 5.0 × 10(-19); rs4908742 near TNFRSF9, p = 0.00020; rs10888503 near LCE3A, p = 0.0014), and two were more strongly associated with PsA than PsC (rs12044149 near IL23R, p = 0.00018; rs9321623 near TNFAIP3, p = 0.00022).
|
26626624 |
2015 |
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Thus, our results suggest that TNFAIP3 (rs610604) and TNIP1 (rs17728338) polymorphisms confer increased risk of psoriasis and may play a vital role in its pathogenesis in our ethnic South Indian Tamils.
|
26738398 |
2015 |
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
According to genome-wide association studies (GWAS), the TNIP1 gene, which encodes the TNF-α-induced protein 3-interacting protein 1 (TNIP1), is strongly linked to the susceptibility of psoriasis.
|
26046540 |
2015 |
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
After our first psoriasis genome-wide association study, we designed a custom genotyping array to fine-map eight genome-wide significant susceptibility loci known at that time (IL23R, IL13, IL12B, TNIP1, MHC, TNFAIP3, IL23A and RNF114) enabling genotyping of 2269 single-nucleotide polymorphisms (SNPs) in the eight loci for 2699 psoriasis cases and 2107 unaffected controls of European ancestry.
|
25182136 |
2015 |
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.
|
25574825 |
2015 |
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
When we compared type I psoriasis with type II psoriasis (N = 36), we found a significant association between age at onset and the genes PSORS6, TNF-α, FCGR2A, TNFR1, CD226, HLA-C, TNFAIP3, and CCHCR1.
|
26613086 |
2015 |
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Thus, the data suggested that HCP5, TNIP1 and TNFAIP3 may play a role in common pathogenic of psoriasis in Chinese and confer risk factors for psoriasis in various ethnic populations.
|
25264125 |
2014 |
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study was to analyse the presence of three different psoriasis susceptibility genetic variations (HLA-Cw6; TNFAIP3 rs610604 polymorphism; LCE3B/3C gene deletions) in a cohort of patients affected by moderate to severe psoriasis under ustekinumab treatment.
|
23521149 |
2013 |
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
|
23143594 |
2012 |
Psoriasis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We found that expression of TNFAIP3 mRNA in all patients negatively correlated with the psoriatic area and severity index (PASI) (r = -0.5126; P = 0.0004) as well as with the percentage of body surface area affected by psoriasis (r = -0.5013; P = 0.0005).
|
23054742 |
2012 |
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
By demonstrating an association with therapeutic response, these results provide a clinically relevant functional correlate to the recently described genetic association between psoriasis and TNFAIP3.
|
22113471 |
2012 |
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
|
23143594 |
2012 |
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
These include TNFAIP3 and TNIP1, which has been implicated in association studies for RA, systemic lupus erythematosus, and psoriasis.
|
21362769 |
2011 |
Psoriasis
|
0.500 |
Biomarker
|
disease |
CTD_human |
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
|
20953190 |
2010 |