|
Osteosarcoma
|
1.000 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Osteosarcoma
|
1.000 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Osteosarcoma
|
1.000 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Osteosarcoma
|
1.000 |
Biomarker
|
disease |
HPO |
|
|
|
|
Osteosarcoma
|
1.000 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Osteosarcoma
|
1.000 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Osteosarcoma
|
1.000 |
Biomarker
|
disease |
MGD |
|
|
|
|
Osteosarcoma
|
1.000 |
SomaticCausalMutation
|
disease |
ORPHANET |
Rearranged p53 genes were also found in human osteogenic sarcoma cell lines.
|
2823272 |
1987 |
|
Osteosarcoma
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
In a survey of 134 human carcinomas, sarcomas, leukemias, and lymphomas obtained at surgery or from peripheral blood, we found rearrangements of the p53 gene only in osteogenic sarcomas (3 of 6 osteogenic sarcomas examined).
|
2823272 |
1987 |
|
Osteosarcoma
|
1.000 |
GermlineCausalMutation
|
disease |
ORPHANET |
Rearranged p53 genes were also found in human osteogenic sarcoma cell lines.
|
2823272 |
1987 |
|
Osteosarcoma
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Identification and characterization of a p53 gene mutation in a human osteosarcoma cell line.
|
2531855 |
1989 |
|
Osteosarcoma
|
1.000 |
Biomarker
|
disease |
BEFREE |
The converse experiment, in which in vitro-translated E1b 58-kDa protein was mixed with lysates of osteosarcoma cells, showed little or no p53-E1b 58-kDa protein association, even though the in vitro E1b 58-kDa protein could associate stably with p53 from cells containing endogenous p53-E1b 58-kDa protein complex.
|
2522559 |
1989 |
|
Osteosarcoma
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Osteosarcoma cell lines with no detectable alteration of the p53 gene contained abundant p53 transcripts.
|
2253237 |
1990 |
|
Osteosarcoma
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
Stable SV40 transformation of the human osteosarcoma cell line HOS yielded SV-HOS cells with high levels of large-T and quasi-original levels of p53.
|
2157184 |
1990 |
|
Osteosarcoma
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
Similarly, we detected homozygous deletion and lack of expression of p53 RNA or aberrant expression of p53 protein in osteosarcomas.
|
2143022 |
1990 |
|
Osteosarcoma
|
1.000 |
Biomarker
|
disease |
BEFREE |
We show that overexpression of the gene encoding wild-type p53 blocks the growth of osteosarcoma cells.
|
2233717 |
1990 |
|
Osteosarcoma
|
1.000 |
Biomarker
|
disease |
BEFREE |
Recent developments of importance include an improved understanding of the importance of the p53 gene in the pathogenesis of osteosarcoma, the description of preclinical models, the development of improved imaging techniques for determining tumor extent and responsiveness to chemotherapy, and refinements in therapy.
|
1932229 |
1991 |
|
Osteosarcoma
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
In contrast to osteosarcoma Saos-2 cells, expression of wild-type or mutant p53 protein in A673 cells had no effect on morphology or growth characteristics.
|
1923505 |
1991 |
|
Osteosarcoma
|
1.000 |
Biomarker
|
disease |
BEFREE |
If both RB1 and TP53 are involved in the initiation of osteosarcoma, the mechanisms for development of the retinoblastoma and osteosarcoma tumors are different.
|
1336709 |
1992 |
|
Osteosarcoma
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Deletion and rearrangement of the p53 gene were also found in three out of five of the human osteosarcoma cell lines (MG-63, G-292, Saos-2).
|
1739619 |
1992 |
|
Osteosarcoma
|
1.000 |
Biomarker
|
disease |
BEFREE |
Therefore, in this case neither RB1 nor TP53 seems to play an essential role in the initiation of osteosarcoma.
|
1423318 |
1992 |
|
Osteosarcoma
|
1.000 |
Biomarker
|
disease |
BEFREE |
This may indicate that either loss of p53 function is etiologically important only for the development of some osteosarcomas, or a major part of p53 gene mutations are subtle ones and their detection requires more sophisticated techniques, which are currently under development.
|
1524989 |
1992 |
|
Osteosarcoma
|
1.000 |
GermlineCausalMutation
|
disease |
ORPHANET |
A germ-line p53 mutation was detected in one of these patients, and a further rearrangement of the residual wild-type allele was detected in tumor tissue. p53 germ-line mutations can contribute to the enhanced predisposition to tumor development manifest in patients with multifocal osteosarcoma.
|
1349175 |
1992 |
|
Osteosarcoma
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Surprisingly, approximately one-half of the osteosarcomas with allelic deletions on 17p did not have detectable alterations in the coding sequence of the p53 gene.
|
1423262 |
1992 |
|
Osteosarcoma
|
1.000 |
Biomarker
|
disease |
BEFREE |
This result suggests that, in addition to the RB (retinoblastoma) gene on 13q and the p53 gene on 17p, at least two more tumor suppressor genes located on 3q and 18q are frequently involved in the development of osteosarcoma.
|
1568211 |
1992 |