Hemangiosarcoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
As a result, only a few mutations were found in angiosarcomas and all of them were single events (no TP53 or TERT mutation).
|
30723294 |
2019 |
Hemangiosarcoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Strong p53 and diffuse c-Myc staining was also significantly associated with AS but not with HSVN or cavernous hemangioma.
|
27090685 |
2016 |
Hemangiosarcoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
No overexpression of TP53 or MDM2 was found, suggesting that the TP53 pathway is not important in angiosarcoma of bone.
|
23599148 |
2013 |
Hemangiosarcoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although p14 inactivation or overexpression of the human murine double minute homolog (HDM2) were frequent in LMS and UPS and could substitute for TP53 mutation or deletion, such alterations were rare in angiosarcomas.
|
22648906 |
2012 |
Hemangiosarcoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Direct sequencing analysis of the TP53 gene showed the presence of at least one variation in 10 of 12 (83.3%) AVL and in seven of eight (87.5%) AS.
|
21323968 |
2011 |
Hemangiosarcoma
|
0.600 |
Biomarker
|
disease |
CTD_mouse |
Final report on carcinogens background document for riddelliine.
|
20737008 |
2008 |
Hemangiosarcoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Although overexpression of p53 and WT-1 has been found in angiosarcoma, little is known about the molecular changes involved.
|
16879020 |
2006 |
Hemangiosarcoma
|
0.600 |
Biomarker
|
disease |
CTD_mouse |
Our data indicated that p53 and beta-catenin mutations in the o-nitrotoluene-induced hemangiosarcomas and K-ras mutations and p53 protein expression in riddelliine-induced hemangiosarcomas most likely occurred as a result of the genotoxic effects of these chemicals.
|
13678655 |
2003 |
Hemangiosarcoma
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Methylated p14(ARF) appeared in the context of a methylated p16(INKa) promoter in 3 cases of the 5 angiosarcomas methylated at p14(ARF). p14(ARF) aberrant methylation was not related to the presence of p53 mutations, which was detected in 6 of 19 (32%) cases.
|
12378512 |
2002 |
Hemangiosarcoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
In vivo, mice doubly deficient for p16(INK4a) and p53 showed an increased rate of tumor formation with particular susceptibility to aggressive angiosarcomas.
|
12019151 |
2002 |
Hemangiosarcoma
|
0.600 |
Biomarker
|
disease |
CTD_mouse |
Our data indicate that K-ras, H-ras, and p53 mutations in these hemangiosarcomas most likely occurred as a result of the genotoxic effects of BD and that these mutations may play a role in the pathogenesis of BD-induced cardiac hemangiosarcomas in the B6C3F1 mouse.
|
10930038 |
2001 |
Hemangiosarcoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The nature of these cells and the abnormalities of the p53 gene and the karyotype, suggest that: i) they were a component of the tumor stroma, and ii) they could have been involved in angiosarcoma development.
|
10952247 |
2000 |
Hemangiosarcoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
The pattern of modification followed the pattern of p53 mutations found in vinyl chloride-associated liver angiosarcomas in humans and rats, but only in regions that showed 100% homology with the human sequence.
|
10626228 |
1999 |
Hemangiosarcoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Previously, a study of p53 gene mutations in tumors of VC-exposed workers found that 50% of liver angiosarcomas contained such mutations.
|
10390705 |
1999 |
Hemangiosarcoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Elevated expression of p53 and MDM-2 protein correlated with increased VEGF expression, which was found in nearly 80% of the angiosarcoma cases.
|
9811333 |
1998 |
Hemangiosarcoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that occurrence of p53 mutation is a major pathway for development of human AS.
|
9185695 |
1997 |
Hemangiosarcoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
No high score for p53 protein expression (i.e., positive staining of >20% of examined cells) was observed; lower scores were seen in 5 of 18 (28%) hepatocellular carcinomas, 1 of 9 (11%) cholangiocarcinomas, and 0 of 8 (0%) hepatic angiosarcomas.
|
8672994 |
1996 |
Hemangiosarcoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These data indicate that p53 mutations are uncommon in sporadic hepatic angiosarcomas (2/21, 9%), and the mutational profile is consistent with endogenous mechanisms.
|
7586214 |
1995 |
Hemangiosarcoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Amplification of MDM2 was not found, but in two of the angiosarcomas an A:T to T:A missense mutation was detected. p53 sequence analysis of vinyl chloride associated cancers may provide valuable information on the relationship between carcinogen exposure and DNA damage in cancer-related genes.
|
8293534 |
1994 |