|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We describe a gene encoding p73, a protein that shares considerable homology with the tumor suppressor p53. p73 maps to 1p36, a region frequently deleted in neuroblastoma and other tumors and thought to contain multiple tumor suppressor genes.
|
9288759 |
1997 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These data suggest that the p73 gene is not playing an essential role, but expression of p73 may associate with tumor growth in prostatic carcinogenesis.
|
9605745 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results suggest that, in CRCs, p73 may not play a role as a tumor suppressor, at least not in a classic Knudson manner.
|
9664127 |
1998 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We report the refined chromosomal localization of the putative tumor suppressor gene TP73 (alias p73) within the genomic region between the anonymous loci D1Z2 and D1S47.
|
9858816 |
1998 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Although most NB tumors expressed p73 within the normal tissue range, wild-type p73 expression levels varied widely in NB and non-NB tumors and NB cell lines with increases up to 90-fold compared with normal tissues.
|
9831242 |
1998 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Since genetic alterations at the tumour suppressor locus 1p36 have been also identified in malignant melanomas, we investigated the expression of p73 in a panel of nine different human melanoma cell lines, 17 melanocytic naevi, 17 primary malignant melanomas and 20 metastases by reverse transcriptase polymerase chain reaction (PCR) and Southern blotting.
|
9918412 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To determine whether p73 is a potential tumor suppressor gene involved in the development of oligodendrogliomas, we performed mutation analysis of p73 in oligodendrogliomas with chromosome 1 p-arm deletions.
|
9721206 |
1998 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In addition, LOH for p73 was found in only 2 of 25 (8%) tumors.
|
9797131 |
1998 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These findings strongly suggest that p73 may play an important role in lung tumorigenesis through activation of a silent allele and overexpression of wild-type p73 rather than as a tumor suppressor.
|
9622072 |
1998 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In 87% of the cases (52/60) p73 expression in tumour was more than twice as high as that in paired normal lung tissues, and the difference between p73 expression in tumour and normal lung tissue was significant (P < 0.0001).
|
10408409 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The role of p73 in tumor development is still unclear and no data on ovarian cancer are so far available.
|
10509157 |
1999 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Quantitative PCR demonstrated that p73 expression is the same in both normal and tumor prostate tissues.
|
10221564 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, although p73 has an ability, comparable to that of p53, to suppress tumor cell growth in p53-deficient cells, p73 induction is regulated differently from p53.
|
10562283 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The p73 gene shares considerable homology with the common tumor suppressor gene p53, both in composition and function.
|
10634515 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The p73 gene is a candidate tumor suppressor gene that has significant homology to p53.
|
10400412 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, we could find no evidence for p73 being the neuroblastoma tumor suppressor gene in 1p36.
|
10341287 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Sequencing of the cDNA for this protein, chronic ulcerative stomatitis protein, revealed it to be homologous to the p53 tumor suppressor and to the p73 putative tumor suppressor, and to be a splicing variant of the KET gene.
|
10469295 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We mapped p73 using radiation hybrids and localized the gene to an interval that putatively harbors a melanoma tumor suppressor locus.
|
9892203 |
1999 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our results suggest that inactivation of the p73 gene does not play a major role in the tumour types analysed in the present study.
|
10218465 |
1999 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
These findings suggest that silencing of the p73 gene by hypermethylation may contribute to development and/or progression of lymphoid neoplasms.
|
10419905 |
1999 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Elevated expression of p73 was frequently observed in carcinoma tissues [18 (40.0%) of 45] and showed a strong correlation with tumor stage or grade.
|
10383132 |
1999 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast, 38% (29 cases) of breast cancers had elevated p73 mRNA ranging from 5-25-fold above normal, with the remaining tumors (64%) falling within the normal range.
|
10397274 |
1999 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We failed to observe a correlation between p73 expression or p53 and apoptosis within a given tumour.
|
10362118 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, p73 is infrequently mutated in primary NBLs and may hardly function as a tumor suppressor in a classic Knudson's manner.
|
10023682 |
1999 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
RT-PCR SSCP analysis of p73 heterozygous cases demonstrated not only bi-allelic expression of the gene but also relatively reduced expression of the affected allele in 6 of 8 tumors with p73 LOH.
|
10471526 |
1999 |