|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Whereas the short (p73beta) isoform accounted for 20-25% of the total p73 mRNA in most of the tumors, these splicing characteristics were altered in ependymomas (only 9% of p73beta) and in neurinomas (up to 53% of p73beta).
|
10213163 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our data indicate that p73 does not play a role as a tumor suppressor in melanoma development.
|
10404074 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These data suggest that the p73 is unlikely to be a tumor suppressor gene, but that overexpression of p73 may contribute to tumorigenesis in bladder cancer.
|
10102633 |
1999 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Sequence analysis of the p73 coding region in the mRNAs expressed by these cell lines and tumors did not reveal inactivating mutations, suggesting that p73 is not homozygously inactivated in neuroblastoma.
|
10935473 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Because p73 encodes for a protein that is both structurally and functionally homologous to the p53 protein, p73 has been postulated to be a candidate tumor suppressor gene.
|
10416592 |
1999 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The early suggestion that monoallelic expression of p73 contributed to carcinogenesis needs to be interpreted cautiously in light of data showing interindividual and intraindividual variation with respect to monoallelic expression of p73 and the finding that p73 mRNA levels are generally increased, rather than decreased, in a host of tumors relative to normal cells.
|
10618710 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall the data suggest that p73 may play an important role in the pathogenesis of neuroblastoma but that the true tumor suppressor gene localized to this area still remains to be identified.
|
10601564 |
2000 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The results suggest that p73 can modulate p53 function by inhibiting its DNA binding and that overexpression of p73 in tumors might be a novel mechanism of inactivation of p53.
|
10606650 |
2000 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Three cell lines with absent p73 protein expression and one tumor sample with monoallelic expression were methylated in the CpG island.
|
11051237 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The p73 gene is thus unlikely to be a tumor suppressor gene for oligodendrogliomas.
|
10953317 |
2000 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Loss of heterozygosity of p73 occurred at relatively low rates in tumors: one of 11 informative samples (9.1%) of ovarian cancer and two of 19 (10.1%) Wilms' tumors.
|
10760569 |
2000 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
DFFB maps to 1p36, near the imprinted putative tumour suppressor gene TP73.
|
10830907 |
2000 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our results demonstrate that p73 expression in this tumor is not regulated by methylation.
|
11002429 |
2000 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Taken together, this study argues that p73 is not a target of genetic alteration in gastric carcinogenesis and suggests that overexpression of p73 might be triggered by physiological stresses accompanied with outgrowth of tumors, such as hypoxia or nutrient deprivation.
|
10815895 |
2000 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In view of the occurrence of 1p deletions in Merkel cell carcinoma (MCC) and the location of p73 we decided to search for mutations in the p73 gene in five MCC cell lines and ten MCC tumours to test potential tumour suppressor function for this gene in MCC.
|
10732753 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that p73 is a biallelically expressed gene in the liver and that allelic loss and mutation of p73 is infrequent and may occur early in HCC. p73 is unlikely to be the putative tumor suppressor gene located at chromosome 1p36 in HCC.
|
10928060 |
2000 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Aberrant expression of the p73 gene was found in 4 (25%) of 16 primary tumors found by mass screening and in 10 (71.4%) of 14 primary tumors found clinically.
|
10719054 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The p63 and p73 genes are rarely mutated in human cancer, although p73 loss is observed in neuroblastoma and a subtype of T-cell lymphoma. p53, p63 and p73 appear to have overlapping and distinct functions: p53 regulates the stress response to suppress tumors; p63 is essential for ectoderm development; and p73 might regulate both the stress response and development.
|
10769197 |
2000 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Informative cases were examined for p73 LOH within the tumour.
|
11720435 |
2001 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We investigated for the first time the genetic and expression status of the p73 gene and analyzed its flanking microsatellite loci on chromosome 1p36.3 in 67 primary oral and laryngeal squamous cell carcinomas to determine their association with these tumors.
|
11323391 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To determine whether p73 is involved in nonastrocytic brain tumour development, we analysed 65 tumour samples including 26 oligodendrogliomas, 4 ependymomas, 5 medulloblastomas, 10 meningiomas, 2 meningeal haemangiopericytomas, 2 neurofibrosarcomas, 3 primary lymphomas, 8 schwannomas and 5 metastatic tumours to the brain, for p73 alterations.
|
11461077 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
More importantly, several candidate tumor suppressor genes such as p16INK4a, p15INK4b, and p73 that were previously reported as unmutated in oligodendroglial tumors were found to be hypermethylated in their CpG islands.
|
11487055 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The interaction between p53 mutants and p63 or p73 was confirmed in a physiological setting by examining tumor cell lines that endogenously express these proteins.
|
11238924 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The protein encoded by p73 shows structural and functional similarities to p53 and may thus represent a candidate tumor suppressor gene.
|
11520574 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The p73 gene, encoding only DeltaN-p73 protein, may function as a tumour promoter rather than a tumour suppressor in liver tissue.
|
11526499 |
2001 |