TP73, tumor protein p73, 7161

N. diseases: 300; N. variants: 19
Disease: Astrocytoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.040 Biomarker disease BEFREE Promoter hypermethylation of the RB1, p14ARF, p15INK4b, p16INK4a, p21Waf1/Cip1, p27Kip1, and p73 genes was detected in 3 (6%), 7 (13%), 4 (7%), 2 (4%), 1 (2%), 3 (6%), and 12 samples (22%) among 54 newly diagnosed malignant astrocytomas, respectively. 17016577 2006
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.040 AlteredExpression disease BEFREE Most of the tumors and non-tumor brain tissues also lacked significant expression of p73 in patients with low-grade astrocytomas. 15138575 2004
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.040 Biomarker disease BEFREE The p73 gene encodes a protein structurally and functionally homologous to TP53, and maps to chromosomal band 1p36.33, where loss of heterozygosity has been observed in up to 90% of oligodendrogliomas and in 10-25% of diffuse astrocytomas. 12200621 2002
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.040 Biomarker disease BEFREE These results suggest that, in astrocytic gliomas, p73 may not play a major role as a tumour suppressor, but the relatively high incidence of LOH confirms the presence at 1p36 of an as yet unidentified gene of this category, with a key function in astrocytoma/GBM progression. 11494043 2001