TP73, tumor protein p73, 7161

N. diseases: 300; N. variants: 19
Disease: Pancreatic carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.040 AlteredExpression disease BEFREE We found that curcumin inhibited cell proliferation and triggered apoptosis in PC, which is associated with increased expression of PTEN and p73. 28535906 2017
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.040 GeneticVariation disease BEFREE Haplotypes of MGMT, MSH6, PMS2, PMS2L3, and TP73 were significantly associated with pancreatic cancer risk (P ≤ 0.0015). 21681824 2012
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.040 AlteredExpression disease BEFREE Western blot analysis and siRNA silencing studies in mutant as well as p53 null cells highlighted a mechanism involving p73 which is also known to be under the regulation of MDM2, and unlike p53, it is rarely mutated in PC. 20156675 2010
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.040 Biomarker disease BEFREE Therapeutic efficacy of E2F1 in pancreatic cancer correlates with TP73 induction. 11585734 2001