C3AR1, complement C3a receptor 1, 719

N. diseases: 73; N. variants: 2
Disease: Cerebrovascular accident ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.040 Biomarker group BEFREE We conclude that the C3aR antagonist, SB 290157, may be used in the future to limit the neuronal death by limiting secondary phagocytosis after stroke. 31814819 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.040 Biomarker group BEFREE Complement C3a receptor (C3aR) is a key mediator of post-ischemic cerebral injury, and pharmacological antagonism of the C3a receptor is neuroprotective in stroke. 31138990 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.040 Biomarker group BEFREE The development of tissue-specific C3aR knockout mice and more specific C3aR antagonists is warranted to facilitate our understanding of the role of the C3aR in brain ischemia with the ultimate goal of clinical translation of therapies targeting C3aR in stroke patients. 31102134 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.040 Biomarker group BEFREE The pathophysiological relevance of C3aR was scrutinized with the use of disease models of myocardial infarction and stroke. 29802205 2018