|
Adult Medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that OGR1 enhances expression of TRPC4-containing channels that contribute to enhanced invasion and metastasis of granule precursor-derived human medulloblastoma.
|
28627017 |
2017 |
|
Alkalosis
|
0.010 |
Biomarker
|
phenotype |
LHGDN |
TRPC4 expression determines sensitivity of the platelet-type capacitative Ca2+ entry channel to intracellular alkalosis.
|
17074721 |
2006 |
|
Cerebellar medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
OGR1 and TRPC4 are prominently expressed in healthy cerebellar tissue throughout postnatal development and in primary cerebellar medulloblastoma tissues.
|
28627017 |
2017 |
|
Childhood Medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that OGR1 enhances expression of TRPC4-containing channels that contribute to enhanced invasion and metastasis of granule precursor-derived human medulloblastoma.
|
28627017 |
2017 |
|
Congenital Hyperinsulinism
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, these studies demonstrate a critical role for PHPT-1 in normal pancreatic β-cell function and raise the possibility that mutations in PHPT-1 and/or TRPC4 may account for yet to be defined cases of CHI.
|
29440278 |
2018 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study indicates that TRPC4 loss in RCC leads to impaired Ca(2+) intake, misfolding, retrograde transport and diminished secretion of antiangiogenic TSP1, thus enabling angiogenic switch during RCC progression.
|
18021253 |
2007 |
|
Diastolic blood pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
|
28135244 |
2017 |
|
Esophageal Neoplasms
|
0.100 |
GeneticVariation
|
group |
GWASDB |
Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions.
|
22960999 |
2012 |
|
Focal cortical dysplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Elevated Expression of TRPC4 in Cortical Lesions of Focal Cortical Dysplasia II and Tuberous Sclerosis Complex.
|
28455787 |
2017 |
|
Graft-vs-Host Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, expression analysis identified PLEC, C8orf48, TRPC4, and ZNF14, as differentially regulated genes in senescent hMSCs that were similarly regulated in those hMSCs which failed to produce a therapeutic effect in a GVHD trial.
|
24496748 |
2014 |
|
Head and Neck Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRPC4 was found to be closely associated with incidence of head and neck cancer and poor survival of patients with kidney cancer.
|
26708603 |
2016 |
|
Hodgkin Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
In accordance, cortisol level tended to be higher in fish fed both supplemented diets at LD compared to fish fed CTRL, but was lower in fish fed TRP4 than in those fed TRP2 under HD condition.
|
31118899 |
2019 |
|
Huntington Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
In accordance, cortisol level tended to be higher in fish fed both supplemented diets at LD compared to fish fed CTRL, but was lower in fish fed TRP4 than in those fed TRP2 under HD condition.
|
31118899 |
2019 |
|
Malignant Head and Neck Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRPC4 was found to be closely associated with incidence of head and neck cancer and poor survival of patients with kidney cancer.
|
26708603 |
2016 |
|
Malignant neoplasm of breast
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Malignant neoplasm of kidney
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRPC4 was found to be closely associated with incidence of head and neck cancer and poor survival of patients with kidney cancer.
|
26708603 |
2016 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The sesquiterpene (-)Englerin A (EA) is an organic compound from the plant Phyllanthus engleri which acts via heteromeric TRPC4/C1 channels to cause cytotoxicity in some types of cancer cell but not normal cells.
|
29209034 |
2017 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
(-)-Englerin A ((-)-EA) has a rapid and potent cytotoxic effect on several types of cancer cell that is mediated by plasma membrane ion channels containing transient receptor potential canonical 4 (TRPC4) protein.
|
27875305 |
2017 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A.
|
30038709 |
2018 |
|
Medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that OGR1 enhances expression of TRPC4-containing channels that contribute to enhanced invasion and metastasis of granule precursor-derived human medulloblastoma.
|
28627017 |
2017 |
|
Myocardial Infarction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We provide evidence for the association of a TRPC4 SNP with MI in population-based genetic studies.
|
21427121 |
2011 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Our results suggest that OGR1 enhances expression of TRPC4-containing channels that contribute to enhanced invasion and metastasis of granule precursor-derived human medulloblastoma.
|
28627017 |
2017 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation.
|
26098886 |
2015 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
The sesquiterpene (-)Englerin A (EA) is an organic compound from the plant Phyllanthus engleri which acts via heteromeric TRPC4/C1 channels to cause cytotoxicity in some types of cancer cell but not normal cells.
|
29209034 |
2017 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
(-)-Englerin A ((-)-EA) has a rapid and potent cytotoxic effect on several types of cancer cell that is mediated by plasma membrane ion channels containing transient receptor potential canonical 4 (TRPC4) protein.
|
27875305 |
2017 |