|
Malignant neoplasm of breast
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Pulmonary Hypertension
|
0.010 |
AlteredExpression
|
phenotype |
LHGDN |
Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension.
|
15358862 |
2004 |
|
Alkalosis
|
0.010 |
Biomarker
|
phenotype |
LHGDN |
TRPC4 expression determines sensitivity of the platelet-type capacitative Ca2+ entry channel to intracellular alkalosis.
|
17074721 |
2006 |
|
Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
LHGDN |
Further analysis revealed a profound decrease in transient receptor potential canonical ion channel 4 (TRPC4) Ca(2+) channel expression in RCC cells.
|
18021253 |
2007 |
|
Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study indicates that TRPC4 loss in RCC leads to impaired Ca(2+) intake, misfolding, retrograde transport and diminished secretion of antiangiogenic TSP1, thus enabling angiogenic switch during RCC progression.
|
18021253 |
2007 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study indicates that TRPC4 loss in RCC leads to impaired Ca(2+) intake, misfolding, retrograde transport and diminished secretion of antiangiogenic TSP1, thus enabling angiogenic switch during RCC progression.
|
18021253 |
2007 |
|
Myocardial Infarction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We provide evidence for the association of a TRPC4 SNP with MI in population-based genetic studies.
|
21427121 |
2011 |
|
Esophageal Neoplasms
|
0.100 |
GeneticVariation
|
group |
GWASDB |
Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions.
|
22960999 |
2012 |
|
Visceral Pain
|
0.200 |
Biomarker
|
phenotype |
RGD |
A rat knockout model implicates TRPC4 in visceral pain sensation.
|
24388923 |
2014 |
|
Graft-vs-Host Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, expression analysis identified PLEC, C8orf48, TRPC4, and ZNF14, as differentially regulated genes in senescent hMSCs that were similarly regulated in those hMSCs which failed to produce a therapeutic effect in a GVHD trial.
|
24496748 |
2014 |
|
Primary Myelofibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Conversely, immunoblotting revealed that Stim2 levels remained constant as compared to N-ECFCs, while Stim1, Orai1, Orai3, TRPC1 and TRPC4 proteins were over-expressed in PMF-ECFCs.
|
24603752 |
2014 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation.
|
26098886 |
2015 |
|
Malignant Head and Neck Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRPC4 was found to be closely associated with incidence of head and neck cancer and poor survival of patients with kidney cancer.
|
26708603 |
2016 |
|
Malignant neoplasm of kidney
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRPC4 was found to be closely associated with incidence of head and neck cancer and poor survival of patients with kidney cancer.
|
26708603 |
2016 |
|
Renal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRPC4 was found to be closely associated with incidence of head and neck cancer and poor survival of patients with kidney cancer.
|
26708603 |
2016 |
|
Head and Neck Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRPC4 was found to be closely associated with incidence of head and neck cancer and poor survival of patients with kidney cancer.
|
26708603 |
2016 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
(-)-Englerin A ((-)-EA) has a rapid and potent cytotoxic effect on several types of cancer cell that is mediated by plasma membrane ion channels containing transient receptor potential canonical 4 (TRPC4) protein.
|
27875305 |
2017 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
(-)-Englerin A ((-)-EA) has a rapid and potent cytotoxic effect on several types of cancer cell that is mediated by plasma membrane ion channels containing transient receptor potential canonical 4 (TRPC4) protein.
|
27875305 |
2017 |
|
Diastolic blood pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
|
28135244 |
2017 |
|
Tuberous Sclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our results indicate that overexpression of TRPC4 protein may be involved in the epileptogenesis of FCD II and TSC.
|
28455787 |
2017 |
|
Focal cortical dysplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Elevated Expression of TRPC4 in Cortical Lesions of Focal Cortical Dysplasia II and Tuberous Sclerosis Complex.
|
28455787 |
2017 |
|
Medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that OGR1 enhances expression of TRPC4-containing channels that contribute to enhanced invasion and metastasis of granule precursor-derived human medulloblastoma.
|
28627017 |
2017 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Our results suggest that OGR1 enhances expression of TRPC4-containing channels that contribute to enhanced invasion and metastasis of granule precursor-derived human medulloblastoma.
|
28627017 |
2017 |
|
Childhood Medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that OGR1 enhances expression of TRPC4-containing channels that contribute to enhanced invasion and metastasis of granule precursor-derived human medulloblastoma.
|
28627017 |
2017 |
|
Adult Medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that OGR1 enhances expression of TRPC4-containing channels that contribute to enhanced invasion and metastasis of granule precursor-derived human medulloblastoma.
|
28627017 |
2017 |