Disease: Parkinson Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.330 Biomarker disease BEFREE Overall, our study identified a new lnc-p21-miR-625-TRPM2 regulatory network that lnc-p21 regulated MPP + -induced neuronal injury by sponging miR-625 and upregulating TRPM2 in SH-SY5Y cells, which provide a better understanding for the pathogenesis of PD. 31004593 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.330 Biomarker disease BEFREE A recent study shows that, 1-methyl-4-phenylpyridine ion (MPP), which selectively causes dopaminergic neuronal death leading to Parkinson's disease-like symptoms, can reduce SH-SY5Y cell viability by inducing H₂O₂ generation and subsequent TRPM2 channel activation. 30625984 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.330 AlteredExpression disease BEFREE Correspondingly, TRPM2 expression was also increased in substantia nigra of MPTP-induced PD mouse model and PD patients. 27957685 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.330 Biomarker disease CTD_human Correspondingly, TRPM2 expression was also increased in substantia nigra of MPTP-induced PD mouse model and PD patients. 27957685 2018