TSC1, TSC complex subunit 1, 7248

N. diseases: 391; N. variants: 155
Disease: Polycystic Kidney - body part ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1567435
Disease: Polycystic Kidney - body part
Polycystic Kidney - body part 		0.010 Biomarker disease BEFREE We document robust FoxO activation in Tsc1-deficient benign polycystic kidneys and FoxO extinction on progression to murine renal tumors; murine renal tumor progression on genetic deletion of both Tsc1 and FoxOs; and downregulated FoxO expression in most human renal clear cell and papillary carcinomas, yet continued expression in less aggressive RCCs and benign renal tumor subtypes. 21075312 2010