|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
Hyperthyroidism occurs due to the presence of stimulating TSHR-autoantibodies (TRAbs) leading to increased serum levels of thyroid hormones.
|
23613015 |
2013 |
|
Hyperthyroidism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Hyperthyroidism and Papillary Thyroid Carcinoma in Thyrotropin Receptor D633H Mutant Mice.
|
30132406 |
2018 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
TSH receptor (TSHR) antibodies and hyperthyroidism are induced by immunizing mice with adenovirus encoding the TSHR or its A-subunit.
|
18927213 |
2009 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
TSH receptor antibody testing should be considered in pregnant women with any history of autoimmune thyroid disease and symptoms of fetal hyperthyroidism.
|
27813690 |
2017 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
A 30-year-old female presented with overt hyperthyroidism and negative thyroid-stimulating hormone receptor antibodies (TRAbs).
|
30897565 |
2019 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
A complex interaction between genetic and environmental factors is the proposed cause which triggers immune system to produce autoantibodies stimulating the TSH receptor, leading to clinical manifestations such as hyperthyroidism, diffuse thyroid enlargement (goiter) and often ophthalmopathy in affected individuals.
|
29890310 |
2018 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
A higher baseline TSH-receptor antibody titre corresponded to a greater improvement in exercise capacity (r=0.76, p<0.05) and physical quality of life (r=0.73, p<0.05) on resolution of the hyperthyroidism.
|
28025026 |
2017 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism.
|
18669595 |
2008 |
|
Hyperthyroidism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A more intense signal was observed in toxic adenomas and in samples obtained from a patient with severe hyperthyroidism due to an activating mutation in the TSH receptor.
|
9225730 |
1997 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
CTD_human |
A neomutation of the thyroid-stimulating hormone receptor in a severe neonatal hyperthyroidism.
|
8964822 |
1996 |
|
Hyperthyroidism
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
A new case of familial nonautoimmune hyperthyroidism caused by the M463V mutation in the TSH receptor with anticipation of the disease across generations: a possible role of iodine supplementation.
|
17696839 |
2007 |
|
Hyperthyroidism
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
A novel activating mutation in transmembrane helix 6 of the thyrotropin receptor as cause of hereditary nonautoimmune hyperthyroidism.
|
16756474 |
2006 |
|
Hyperthyroidism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A Phe 486 thyrotropin receptor mutation in an autonomously functioning follicular carcinoma that was causing hyperthyroidism.
|
11128715 |
2000 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
A recent study on TSH receptor (TSHR) null mice suggested that skeletal loss occurring in hyperthyroidism is caused by the low TSH rather than high thyroid hormone levels.
|
17656602 |
2007 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
A T cell line established from a mouse with hyperthyroidism proliferates in response to fibroblasts expressing a class II molecule and TSHR, but not to the fibroblasts expressing only TSHR, indicating that the class II molecules on the fibroblasts present TSHR-derived peptide(s) to T cells.
|
11129118 |
2000 |
|
Hyperthyroidism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Activating TSHR mutations are a rare cause of nonautoimmune adult hyperthyroidism.
|
30372544 |
2019 |
|
Hyperthyroidism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Activating germline mutations of the TSH receptor are rare etiologies for hyperthyroidism.
|
28648513 |
2017 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
Although TSH-receptor autoantibodies (TRAb) were negative, the persistence of hyperthyroidism, the hypervascular pattern at thyroid ultrasound, and the high uptake at thyroid scintigraphy were all features suggestive of Graves' disease.
|
31602361 |
2019 |
|
Hyperthyroidism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Although hereditary nonautoimmune overt hyperthyroidism is very rare, TSHR activating mutations as a cause of subclinical hyperthyroidism may be more common and should be considered in the differential diagnosis, especially if familial.
|
20929407 |
2010 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
Among them, two patients (patient 1 and 4) were hyperthyroid and TSH receptor antibody (TRAb) positive, two patients (patient 3 and 5) were euthyroid and displayed slightly elevated TRAb titres, one patient (patient 2) was euthyroid and TRAb negative.
|
29381976 |
2017 |
|
Hyperthyroidism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
An identical germline TSH-R mutation was detected in all the patients with hyperthyroidism but in none of the unaffected family members.
|
12240901 |
2002 |
|
Hyperthyroidism
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
An identical germline TSH-R mutation was detected in all the patients with hyperthyroidism but in none of the unaffected family members.
|
12240901 |
2002 |
|
Hyperthyroidism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Based on a literature search regarding all published TSHR mutations, this review covers several mutations which are clearly associated with a hyperthyroidism-phenotype, but interestingly show a lack of constitutive activity determined by in vitro characterization.
|
24845969 |
2014 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
Because Graves' hyperthyroidism is preferentially induced in BALB/c mice using adenovirus encoding the free A-subunit rather than full-length human TSHR, the shed A-subunit appears to drive the disease-associated autoimmune response.
|
16365463 |
2006 |