|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
The current study was primarly carried out to compare the diagnostic effectiveness of two TSH receptor antibody immunoassays (IMAs), ultrasonography and thyroid scintigraphy in hyperthyroidism scenario.
|
31742747 |
2020 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
This study explores the first-in-human use of antigen-specific immunotherapy with a combination of two thyrotropin receptor (TSHR) peptides (termed ATX-GD-59) in Graves' hyperthyroidism.
|
31194638 |
2019 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
A 30-year-old female presented with overt hyperthyroidism and negative thyroid-stimulating hormone receptor antibodies (TRAbs).
|
30897565 |
2019 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
HT is characteristic of hypothyroidism resulting from the destruction of the thyroid while GD is characteristic of hyperthyroidism due to excessive production of thyroid hormone induced by thyrotropin receptor-specific stimulatory autoantibodies.
|
30246383 |
2019 |
|
Hyperthyroidism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The disease is caused by the appearance of stimulating TSH receptor autoantibodies (TRAb) leading to hyperthyroidism.
|
30468646 |
2019 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
Although TSH-receptor autoantibodies (TRAb) were negative, the persistence of hyperthyroidism, the hypervascular pattern at thyroid ultrasound, and the high uptake at thyroid scintigraphy were all features suggestive of Graves' disease.
|
31602361 |
2019 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
One patient developed TSH-receptor-antibody-positive hyperthyroidism 6 months after the onset of DRESS, while another patient developed chronic urticaria 4 months after resolution of DRESS.
|
30920020 |
2019 |
|
Hyperthyroidism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Activating TSHR mutations are a rare cause of nonautoimmune adult hyperthyroidism.
|
30372544 |
2019 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
The thyrotropin receptor (TSHR) is the target for autoimmune thyroid stimulating antibodies (TSAb) triggering hyperthyroidism.
|
30351237 |
2019 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
The Relation Between Epicardial Fat Tissue Thickness and TSH Receptor Antibody in Hyperthyroidism.
|
30107622 |
2019 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
It usually presents as a component of the syndrome known as Graves' disease where loss of immune tolerance to the thyrotropin receptor (TSHR) results in the generation of activating antibodies against that protein and hyperthyroidism.
|
29273685 |
2018 |
|
Hyperthyroidism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Hyperthyroidism and Papillary Thyroid Carcinoma in Thyrotropin Receptor D633H Mutant Mice.
|
30132406 |
2018 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
Combination testing of ihTRAb and TPOAb at baseline predicted 20% of subsequent cases of hyperthyroidism and 83% of hypothyroidism.
|
30351224 |
2018 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
A complex interaction between genetic and environmental factors is the proposed cause which triggers immune system to produce autoantibodies stimulating the TSH receptor, leading to clinical manifestations such as hyperthyroidism, diffuse thyroid enlargement (goiter) and often ophthalmopathy in affected individuals.
|
29890310 |
2018 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
Graves´ disease is an autoimmune disorder, which is characterized by stimulatory antibodies targeting the human thyrotropin receptor (TSHR), resulting in hyperthyroidism and multiple organ damage.
|
29772544 |
2018 |
|
Hyperthyroidism
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
GTT was defined as hyperthyroidism (free thyroxine [FT4] level: ≥95th percentile) in the early pregnancy, which normalized in mid-pregnancy without thyroid-stimulating hormone receptor antibodies.
|
27766407 |
2017 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
A higher baseline TSH-receptor antibody titre corresponded to a greater improvement in exercise capacity (r=0.76, p<0.05) and physical quality of life (r=0.73, p<0.05) on resolution of the hyperthyroidism.
|
28025026 |
2017 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
TSH receptor antibody testing should be considered in pregnant women with any history of autoimmune thyroid disease and symptoms of fetal hyperthyroidism.
|
27813690 |
2017 |
|
Hyperthyroidism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Activating germline mutations of the TSH receptor are rare etiologies for hyperthyroidism.
|
28648513 |
2017 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
Thyrotropin (TSH) receptor antibodies (TRAb) mediate the hyperthyroidism of Graves' disease (GD).
|
28737965 |
2017 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
Stimulating TSH receptor antibiodies increased DII activities via their nongenomic effects using sera of hyperthyroid Graves' ophthalmopathy, but anti-TPO antibodies could influence DII activities via altering FT<sub>4</sub> levels.
|
28750432 |
2017 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
Among them, two patients (patient 1 and 4) were hyperthyroid and TSH receptor antibody (TRAb) positive, two patients (patient 3 and 5) were euthyroid and displayed slightly elevated TRAb titres, one patient (patient 2) was euthyroid and TRAb negative.
|
29381976 |
2017 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
Expert opinion: Those agents that can interrupt the TSHR and IGF-IR pathways possess the potential for offering more specific and better tolerated treatments of both hyperthyroidism and TAO.
|
28127991 |
2017 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
Previously, in an induced mouse model, injecting TSHR A-subunit protein attenuated hyperthyroidism by diverting pathogenic TSHR Abs to a nonfunctional variety.
|
27913646 |
2016 |
|
Hyperthyroidism
|
0.500 |
Biomarker
|
disease |
BEFREE |
Graves' disease is an autoimmune disorder that causes hyperthyroidism because of autoantibodies that bind to the thyroid-stimulating hormone receptor (TSHR) on the thyroid gland, triggering thyroid hormone release.
|
26787873 |
2016 |