|
Thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Gain-of-function mutations in the TSH receptor and the Galpha(S) subunit occur frequently in hyperfunctioning thyroid nodules and differentiated thyroid carcinomas, whereby the T allele of a common polymorphism (825C>T, rs5443) in the G protein beta3 subunit gene (GNB3) is associated with increased G protein-mediated signal transduction and a complex phenotype.
|
19772422 |
2009 |
|
Thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Mutations L677V and T620I identified in hot thyroid carcinomas were previously characterized in CHO and in 3T3-Vill cell lines, respectively, stably expressing the mutant without determination of TSHR expression.
|
20846293 |
2010 |
|
Thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to investigate the presence TSHR gene mutations in a series of thyroid specimens obtained from 22 consecutive patients with differentiated thyroid carcinomas (8 follicular and 14 papillary).
|
10342361 |
1999 |
|
Thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The promoter region of TSHR gene was found to be methylated in 25 % (15 of 60) of the thyroid cancer patients.
|
24927793 |
2014 |
|
Thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No evidence of thyrotropin receptor and G(s alpha) gene mutation in high iodine uptake thyroid carcinoma.
|
11041453 |
2000 |
|
Thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this paper we report the results of a screen for structural defects in exon 10 of the TSH-R (which includes the whole serpentine structure, but not the extracellular domain) and of Gs alpha in 30 thyroid carcinomas.
|
8923835 |
1996 |
|
Thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
As such, this article addresses the following aspects of intragenic mutations in thyroid cancer: thyroid stimulating hormone receptor and guanine-nucleotide-binding proteins of the stimulatory family mutations in hyperfunctioning tumors; mutations in RAS and other genes and aneuploidy; PAX8-PPARgamma rearrangements; BRAF mutations; mutations in oxidative phosphorylation and Krebs cycle genes in Hürthle cell tumors; mutations in succinate dehydrogenase genes in medullary carcinoma and C-cell hyperplasia; and mutations in TP53 and other genes in poorly differentiated and anaplastic carcinomas.
|
18502330 |
2008 |
|
Thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas.
|
8413627 |
1993 |
|
Thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
As disturbed thyrotropin receptor signaling plays a central role in hot thyroid nodules, the identification of effective low-molecular-weight thyrotropin receptor ligands, such as thyrotropin receptor agonists, inverse agonists and antagonists has a pharmacologic potential in the diagnosis and treatment of thyroid cancer, Graves' disease and hot thyroid nodules, respectively.
|
17940470 |
2007 |
|
Thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition, there was no correlation between NIS and TSHR in thyroid cancer, which may explain why, even after TSH stimulation, 10-20% of these malignant tumors are unable to concentrate enough radioiodine for effective therapy.
|
21989446 |
2012 |
|
Thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Activating mutations of the TSH receptor in differentiated thyroid carcinomas.
|
7478621 |
1995 |
|
Thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Methylation of thyroid-specific genes, such as those for sodium/iodide symporter and thyroid-stimulating hormone receptor, is also common in thyroid cancer.
|
16946009 |
2007 |
|
Thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
In order to further evaluate the role of TSH in the proliferation and the differentiation of human thyroid carcinoma cells, we have analyzed the function of the TSH receptor in the established thyroid carcinoma cell lines NPA and WRO.
|
1333981 |
1992 |
|
Thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Lastly, future investigation of epigenetic events occurring at the TSHR and other loci may give better clues for molecular based therapy of undifferentiated thyroid carcinomas.
|
17891229 |
2007 |
|
Thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thyroid-stimulating hormone receptor messenger ribonucleic acid measurement in blood as a marker for circulating thyroid cancer cells and its role in the preoperative diagnosis of thyroid cancer.
|
17118994 |
2007 |
|
Thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The present study indicates the normal patterns of DNA and RNA hybridization in a variety of thyroid tissues and disease states, and demonstrates that pathologic thyroid samples, with the possible exception of thyroid cancer, were not associated with specific nucleotide abnormalities in the unique area of the TSH receptor that was studied.
|
1420806 |
1992 |
|
Thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recently, the value of thyroid-stimulating hormone receptor(TSHR) mRNA as a molecular marker in diagnosis of thyroid cancer has been greatly explored.
|
20429628 |
2010 |
|
Thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our meta-analysis suggests that TSHR-mRNA might be a potential biomarker to complete present diagnostic methods for early and precision diagnosis of thyroid cancer.
|
28036261 |
2017 |
|
Thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
We, therefore, isolated neomycin-resistant stable human thyroid carcinoma cell (WRO cell) transfectants overexpressing intact human TSH receptor to evaluate the functional role of TSH receptor on carcinoma cells.
|
8381075 |
1993 |
|
Thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we present an example of the construction of silicon dioxide nanoparticles with thyroid-stimulating-hormone receptor-targeting ligand that can specifically target the thyroid cancer.
|
28860762 |
2017 |
|
Thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
Detection of an activating mutation of the thyrotropin receptor in a case of an autonomously hyperfunctioning thyroid insular carcinoma.
|
9062474 |
1997 |
|
Thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition, the prognostic value of TSHR in thyroid cancer was analyzed.
|
29344196 |
2017 |
|
Thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
We transfected human thyroid carcinoma cells lacking an endogenous TSH receptor with the human TSH receptor cDNA.
|
8385451 |
1993 |
|
Thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
These studies evaluating the etiological roles of these factors in linking breast and thyroid cancer might also improve our understanding and identify new therapeutic approaches, such as sodium/iodide symporter-mediated radioiodine therapy and thyroid-stimulating hormone receptor antagonists, for breast cancer.
|
29976206 |
2018 |