|
Thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Preoperative thyrotropin receptor messenger RNA was measured in 9 patients: 3 of 4 with thyroid cancer had elevated levels and 3 of 5 with goiters undetectable.
|
22244412 |
2012 |
|
Thyroid carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Different expression of TSH receptor and NIS genes in thyroid cancer: role of epigenetics.
|
24353283 |
2014 |
|
Thyroid carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The mRNA expression levels of CSC- (CD133 and CD44) and ES-related genes (Oct4 and Nanog) were higher in TC tissue than in normal thyroid tissue, whereas the mRNA expression levels of thyroid-specific genes (Tg, TSHR, and TTF1) were higher in normal thyroid tissue than in TC tissue.
|
30160089 |
2018 |
|
Thyroid carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
All of the transcripts obtained from thyroid carcinomas (both primary and metastatic) were of the same size as the transcripts from normal or benign thyroid tissues, with the exception of 2 cases of differentiated thyroid cancer, in which TSH-R mRNA of lower mol wt (approximately 4.0 kilobases) was found in the absence of alteration in cDNA size and restriction map.
|
8157713 |
1994 |
|
Thyroid carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We have established that thyroid hormone receptor beta1 (TRbeta1) is associated with the loss of TSHR gene expression in an anaplastic human thyroid cancer cell line, ARO.
|
12429043 |
2002 |
|
Thyroid carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
TSHR mRNA also represents a new blood test to aid assessment of disease status in thyroid cancer follow-up.
|
20881771 |
2010 |
|
Thyroid carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
This review examines the evidence for TSHR signaling as an oncogenic pathway and assesses the evidence for ongoing TSHR expression in thyroid cancer metastases.
|
28351942 |
2017 |
|
Thyroid carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Qualitative analysis of baseline and stimulated TG, NIS and PDS mRNA showed high sensitivity but low specificity in the prediction of thyroid cancer recurrence or metastases (accuracy under THST = 51%, 43% and 54%, respectively), whereas TPO and TSHR mRNA assays had higher specificity but low sensitivity, with accuracy under THST of 67% and 61%, respectively, that improved when these tests were combined.
|
15170676 |
2004 |
|
Thyroid carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
TSH receptor mRNA reverse transcription-polymerase chain reaction, the Veracyte and Asuragen commercial methods, and the noncommercial use of BRAF, RAS, RET/PTC, and PAX8/PPARγ testing have promising roles in the diagnosis and treatment of patients with nodular thyroid disease and thyroid cancer.
|
22984796 |
2013 |
|
Thyroid carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry showed the positive expression of NIS and TSHR in thyroid cancer group.
|
30058701 |
2018 |
|
Thyroid carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of thyroid hormone receptor beta1 is associated with thyrotropin receptor gene expression and proliferation in a human thyroid carcinoma cell line.
|
10810302 |
2000 |
|
Thyroid carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, monoclonal antibodies such as 5C9 may well provide the basis of new drugs to control TSHR activity including applications in thyroid cancer and Graves' ophthalmopathy.
|
18631002 |
2008 |
|
Thyroid carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Among these, thyroglobulin, and more recently thyroid-stimulating hormone receptor mRNAs' provide high diagnostic sensitivity and specificity for thyroid cancer detection.
|
17940468 |
2007 |
|
Thyroid carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
TSH-R expression was normal in most tissues studied and was decreased in only some thyroid carcinomas.
|
10487692 |
1999 |
|
Thyroid carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Circulating thyroid cancer cells detected by peripheral blood thyroid-stimulating hormone receptor (TSHR) mRNA have demonstrated usefulness for thyroid cancer diagnosis and long-term surveillance.
|
19958935 |
2009 |
|
Thyroid carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In the present study we compared the TSH receptor and c-myc mRNA levels in different stages of thyroid carcinomas to identify whether they are useful markers for thyroid tumour biological behaviour and prognosis.
|
8222289 |
1993 |
|
Thyroid carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Detection of thyrotropin-receptor messenger ribonucleic acid (mRNA) and thyroglobulin mRNA transcripts in peripheral blood of patients with thyroid disease: sensitive and specific markers for thyroid cancer.
|
15292293 |
2004 |
|
Thyroid carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Structural insight at atomic resolution of a TSHR antibody with inverse agonist activity opens the way for the development of a molecule with therapeutic potential, particularly in thyroid carcinoma.
|
29845889 |
2018 |
|
Thyroid carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
It is proposed that the constitutively activated TSHR genes detected in the thyroid carcinomas, may have played an oncogenic role, participating in their development through these two pathways.
|
11039907 |
2000 |