|
Gonadoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Gonadoblastoma Y locus genes expressed in germ cells of individuals with dysgenetic gonads and a Y chromosome in their karyotypes include DDX3Y and TSPY.
|
30753444 |
2019 |
|
Gonadoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
If a gonad in those individuals contains germ cells with delayed maturation and also harbors the TSPY1 gene, the cells can undergo transformation to classical gonadoblastoma.
|
31805291 |
2019 |
|
Gonadoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TSPY is the putative gene for the gonadoblastoma locus on the Y chromosome (GBY) that is ectopically expressed in a subset of male hepatocellular carcinomas (HCCs).
|
30867900 |
2019 |
|
Gonadoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Undifferentiated gonadal tissue is the precursor of classical gonadoblastoma and contains germ cells with delayed maturation that express octamer-binding transcription factor 4 (OCT4); however, other germ cells show normal maturation and express TSPY1.
|
28881049 |
2018 |
|
Gonadoblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
DSD patients with specific Y-chromosomal material in their karyotype, the GonadoBlastoma on the Y-chromosome (GBY) region, have an increased risk of developing type II germ cell tumors/cancer (GCC), most likely related to TSPY.
|
23157850 |
2012 |
|
Gonadoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Positive OCT3/4 staining was present in all gonadoblastomas and dysgerminomas investigated, TSPY expression was only seen in the gonadoblastoma/dysgerminoma lesions of the 16 DSD patients.
|
22937135 |
2012 |
|
Gonadoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The testis-specific protein Y-linked (TSPY) repeat gene has recently been demonstrated to be the putative gene for GBY, based on its location on the GBY critical region, expression patterns in early and late stages of gonadoblastoma and ability to induce gonadoblastoma-like structures in the ovaries of transgenic female mice.
|
21204751 |
2011 |
|
Gonadoblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Significant amounts of TSPY gene were found in seven cases, two of which had gonadoblastoma and one had cytogenetic proof of Y chromosome presence.
|
21752796 |
2011 |
|
Gonadoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
From a clinical perspective, our data show that interphase fluorescence in situ hybridization targeting TSPY1 is a straightforward approach that can be used in the evaluation of Y-associated intersex disorders in women who develop gonadoblastoma.
|
20656323 |
2010 |
|
Gonadoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies establish the testis-specific protein Y-encoded (TSPY) gene to be the putative gene for GBY.
|
19306348 |
2009 |
|
Gonadoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TSPY protein localized with established germ cell tumor markers, such as the placental alkaline phosphatase, c-KIT, and OCT3/4, in the same tumor cells of both gonadoblastoma and adjacent carcinoma in situ, the precursor for germ cell tumors.
|
17349529 |
2007 |
|
Gonadoblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The testis-specific protein Y-encoded (TSPY) gene is the putative gene for the gonadoblastoma locus on the Y chromosome (GBY) that predisposes dysgenetic gonads of intersex patients to gonadoblastoma development.
|
17521702 |
2007 |
|
Gonadoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, tissue from five phenotypic female patients harbouring combined dysgerminoma/gonadoblastoma expressed TSPY and contained Y-chromosome material as confirmed by FISH.
|
17274819 |
2007 |
|
Gonadoblastoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
The testis-specific protein Y-encoded (TSPY) gene is the putative gene for the gonadoblastoma locus on the Y chromosome (GBY) that predisposes dysgenetic gonads of intersex patients to gonadoblastoma development.
|
17521702 |
2007 |
|
Gonadoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Testis-specific protein Y-encoded (TSPY) gene may participate in the oncogenesis of gonadoblastoma expression of TSPY in the tumor tissue.
|
16784771 |
2006 |
|
Gonadoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Elevated levels of TSPY have been observed in gonadoblastoma specimens and a variety of other tumor tissues, including testicular germ cell tumors, prostate cancer, melanoma, and liver cancer.
|
16762081 |
2006 |
|
Gonadoblastoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3/4 and TSPY.
|
15948118 |
2005 |
|
Gonadoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The testis-specific protein Y-encoded (TSPY) gene is a candidate for the gonadoblastoma locus on the Y chromosome and is expressed in normal testicular germ cells and gonadoblastoma cells of XY sex-reversed females.
|
16035036 |
2005 |
|
Gonadoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TSPY, a candidate gene for a factor that promotes gonadoblastoma formation (GBY), is a testis-specific multicopy gene family in the male-specific region of the human Y (MSY) chromosome.
|
15241014 |
2004 |
|
Gonadoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the exact nature of such variant TSPY transcripts and proteins is still unclear, their differential expression suggests that the TSPY gene may also be involved in the multi-step prostatic oncogenesis besides its putative role in gonadoblastoma and testicular seminoma.
|
14684991 |
2003 |
|
Gonadoblastoma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Gonadoblastoma, testicular and prostate cancers, and the TSPY gene.
|
10090875 |
1999 |
|
Gonadoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results confirm the high level of TSPY protein expression by these cells and demonstrate the value of this antibody as an additional marker to confirm the diagnosis of gonadoblastoma.
|
10629567 |
1999 |