Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.380 AlteredExpression disease BEFREE Pleckstrin homology-like domain family A member 2 (PHLDA2) displays low expression in human osteosarcoma as a proapoptosis factor. miRNAs have been shown to be important in modulating translation and therapeutic responsiveness in solid tumors. 31058093 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.380 AlteredExpression disease BEFREE Then, we showed that TSSC3 overexpression enhanced autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway in osteosarcoma. 30092789 2018
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.380 AlteredExpression disease BEFREE Overall, our study demonstrates that TSSC3 inhibits the stem-like phenotype and Nanog expression by inactivation of the Src/Akt pathway; this emphasizes the importance of Nanog in osteosarcoma stem cells. 29156746 2017
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.380 AlteredExpression disease BEFREE TSSC3 expression (P=0.032, HR=0.405, 95%CI=0.177-0.926) and metastasis (P=0.010, HR=2.849, 95%CI=1.291-6.287) were considered to be independent prognostic factors in osteosarcoma. 27044808 2016
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.380 Biomarker disease BEFREE Our previous study showed that TSSC3 acts as a tumor suppressor in osteosarcoma. 26265454 2015
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.380 AlteredExpression disease BEFREE Taken together, these observations suggest that the epigenetic regulation of TSSC3, a pro-apoptosis gene, provides valuable insights into possible osteosarcoma therapies. 24268429 2014
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.380 Biomarker disease BEFREE These findings support a suppressor role for TSSC3 in osteosarcoma development by regulating apoptosis. 22021909 2012
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.380 Therapeutic disease CTD_human These findings support a suppressor role for TSSC3 in osteosarcoma development by regulating apoptosis. 22021909 2012
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.380 AlteredExpression disease BEFREE Furthermore, overexpression of TSSC3 was found to induce apoptosis of OS T-ICs through increasing cleaved caspase-3 (active form), increasing the release of Cyt c and decreasing pro-caspase-9 (pro-enzyme form), as well as disruption of the mitochondrial membrane potential (ΔΨ). 22610481 2012
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.300 Biomarker disease PSYGENET Combining evidence from the case-control study, the follow-up in families, and gene expression provided strongest support for the association of a cluster of genes on chromosome 11 (SLC22A18, PHLDA2, NAP1L4, SNORA54, CARS, and OSBPL5) with alcohol dependence. 20201924 2010
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.300 Biomarker disease CTD_human Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839). 15496427 2004
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.080 AlteredExpression disease BEFREE Pleckstrin homology-like domain family A member 2 (PHLDA2) displays low expression in human osteosarcoma as a proapoptosis factor. miRNAs have been shown to be important in modulating translation and therapeutic responsiveness in solid tumors. 31058093 2019
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.080 AlteredExpression disease BEFREE Pleckstrin homology-like domain family A member 2 (PHLDA2) displays low expression in human osteosarcoma as a proapoptosis factor. miRNAs have been shown to be important in modulating translation and therapeutic responsiveness in solid tumors. 31058093 2019
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.080 AlteredExpression disease BEFREE Then, we showed that TSSC3 overexpression enhanced autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway in osteosarcoma. 30092789 2018
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.080 AlteredExpression disease BEFREE Then, we showed that TSSC3 overexpression enhanced autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway in osteosarcoma. 30092789 2018
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.080 AlteredExpression disease BEFREE Overall, our study demonstrates that TSSC3 inhibits the stem-like phenotype and Nanog expression by inactivation of the Src/Akt pathway; this emphasizes the importance of Nanog in osteosarcoma stem cells. 29156746 2017
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.080 AlteredExpression disease BEFREE Overall, our study demonstrates that TSSC3 inhibits the stem-like phenotype and Nanog expression by inactivation of the Src/Akt pathway; this emphasizes the importance of Nanog in osteosarcoma stem cells. 29156746 2017
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.080 AlteredExpression disease BEFREE TSSC3 expression (P=0.032, HR=0.405, 95%CI=0.177-0.926) and metastasis (P=0.010, HR=2.849, 95%CI=1.291-6.287) were considered to be independent prognostic factors in osteosarcoma. 27044808 2016
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.080 AlteredExpression disease BEFREE TSSC3 expression (P=0.032, HR=0.405, 95%CI=0.177-0.926) and metastasis (P=0.010, HR=2.849, 95%CI=1.291-6.287) were considered to be independent prognostic factors in osteosarcoma. 27044808 2016
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.080 Biomarker disease BEFREE Our previous study showed that TSSC3 acts as a tumor suppressor in osteosarcoma. 26265454 2015
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.080 Biomarker disease BEFREE Our previous study showed that TSSC3 acts as a tumor suppressor in osteosarcoma. 26265454 2015
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.080 AlteredExpression disease BEFREE Taken together, these observations suggest that the epigenetic regulation of TSSC3, a pro-apoptosis gene, provides valuable insights into possible osteosarcoma therapies. 24268429 2014
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.080 AlteredExpression disease BEFREE Taken together, these observations suggest that the epigenetic regulation of TSSC3, a pro-apoptosis gene, provides valuable insights into possible osteosarcoma therapies. 24268429 2014
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.080 AlteredExpression disease BEFREE Furthermore, overexpression of TSSC3 was found to induce apoptosis of OS T-ICs through increasing cleaved caspase-3 (active form), increasing the release of Cyt c and decreasing pro-caspase-9 (pro-enzyme form), as well as disruption of the mitochondrial membrane potential (ΔΨ). 22610481 2012
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.080 Biomarker disease BEFREE These findings support a suppressor role for TSSC3 in osteosarcoma development by regulating apoptosis. 22021909 2012