TTC4, tetratricopeptide repeat domain 4, 7268

N. diseases: 32; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia 		0.010 Biomarker disease BEFREE This study compared the treatment outcomes of patients overall and patients with a non-CNS-1 status (CNS-2, CNS-3, or TLP with blasts) in 2 treatment eras, one before and another after the revision of the TPOG-ALL-2002 protocol by the introduction of the modification (era 1 [2002-2008] with CrRT and era 2 [2009-2012] with delayed first TIT and no CrRT). 30303520 2018
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia 		0.010 Biomarker disease BEFREE Patients enrolled on Children's Cancer Group protocols 2861, 2891, 2941, and 2961 being treated for de novo AML were classified for the presence of CNS disease at diagnosis as CNS1 (<5 WBC in the CSF without blasts), CNS2 (<5 WBC in the CSF with blasts), or CNS3 (> or =5 WBC in the CSF with blasts). 20658610 2010
CUI: C0751606
Disease: Adult Acute Lymphocytic Leukemia
Adult Acute Lymphocytic Leukemia 		0.010 Biomarker disease BEFREE This study compared the treatment outcomes of patients overall and patients with a non-CNS-1 status (CNS-2, CNS-3, or TLP with blasts) in 2 treatment eras, one before and another after the revision of the TPOG-ALL-2002 protocol by the introduction of the modification (era 1 [2002-2008] with CrRT and era 2 [2009-2012] with delayed first TIT and no CrRT). 30303520 2018
CUI: C1541317
Disease: Adult Gliosarcoma
Adult Gliosarcoma 		0.010 Biomarker disease BEFREE Comparisons of CNS-1 to 9L gliosarcoma tumor were made. 7760095 1994
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.030 AlteredExpression disease BEFREE A preliminary screen of human breast cancer cell lines shows that TTC4 is expressed in all cases, but SSCP analysis of the coding region of this gene following RT-PCR failed to reveal any mutations. 9933562 1999
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.030 GeneticVariation disease BEFREE The gene was originally identified as being localized in a genomic region linked to breast cancer and subsequent studies on melanoma cell lines revealed point mutations in the TTC4 protein that may be associated with the progression of malignant melanoma. 18320024 2008
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.030 Biomarker disease BEFREE Other members of this gene family have been implicated in tumorigenesis suggesting that TTC4 may represent a breast cancer tumor suppressor gene. 10639601 2000
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.010 Biomarker phenotype BEFREE Other members of this gene family have been implicated in tumorigenesis suggesting that TTC4 may represent a breast cancer tumor suppressor gene. 10639601 2000
CUI: C0023452
Disease: Childhood Acute Lymphoblastic Leukemia
Childhood Acute Lymphoblastic Leukemia 		0.010 Biomarker disease BEFREE This study compared the treatment outcomes of patients overall and patients with a non-CNS-1 status (CNS-2, CNS-3, or TLP with blasts) in 2 treatment eras, one before and another after the revision of the TPOG-ALL-2002 protocol by the introduction of the modification (era 1 [2002-2008] with CrRT and era 2 [2009-2012] with delayed first TIT and no CrRT). 30303520 2018
CUI: C3899658
Disease: Childhood Gliosarcoma
Childhood Gliosarcoma 		0.010 Biomarker disease BEFREE Comparisons of CNS-1 to 9L gliosarcoma tumor were made. 7760095 1994
CUI: C0007682
Disease: CNS disorder
CNS disorder 		0.020 Biomarker group BEFREE Methods CSF status was designated as follows: CNS1, no blasts; CNS2a to 2c, < 5 WBCs/μL and blasts with/without ≥ 10 RBCs/μL or ≥ 5 WBCs/μL plus blasts, with WBCs ≥ 5 times the number of RBCs; CNS3a to 3c, ≥ 5 WBCs/μL plus blasts with/without ≥ 10 RBCs/μL or clinical signs of CNS disease. 28535084 2017
CUI: C0007682
Disease: CNS disorder
CNS disorder 		0.020 Biomarker group BEFREE Patients enrolled on Children's Cancer Group protocols 2861, 2891, 2941, and 2961 being treated for de novo AML were classified for the presence of CNS disease at diagnosis as CNS1 (<5 WBC in the CSF without blasts), CNS2 (<5 WBC in the CSF with blasts), or CNS3 (> or =5 WBC in the CSF with blasts). 20658610 2010
CUI: C0686377
Disease: CNS metastases
CNS metastases 		0.010 Biomarker phenotype BEFREE CNS status was classified as CNS1 (no blast cells in CSF; n=205), CNS2 (<5 WBC/mul CSF with blast cells; n=37), or CNS3 (>/=5 WBC/mul CSF with blast cells, or signs of CNS involvement; n=48). 14523477 2003
CUI: C0010324
Disease: Crigler Najjar syndrome, type 1
Crigler Najjar syndrome, type 1 		0.010 GeneticVariation disease BEFREE In patients with complete UGT1A1 deficiency (type 1 CNS [CNS-I]), unconjugated bilirubin levels increase 3-6 mg/dL/day during the newborn period and reach neurologically dangerous levels between 5 and 14 days of age. 31495946 2019
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.010 GeneticVariation disease BEFREE TTC4, a novel candidate tumor suppressor gene at 1p31 is often mutated in malignant melanoma of the skin. 11126369 2000
CUI: C0011847
Disease: Diabetes
Diabetes 		0.010 Biomarker disease BEFREE We show that CNS1 knockout decreased the frequency of pTregs and increased the risk of diabetes. 29604048 2018
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.010 Biomarker group BEFREE We show that CNS1 knockout decreased the frequency of pTregs and increased the risk of diabetes. 29604048 2018
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.010 Biomarker disease BEFREE CNS1 deletion also did not alter the development of T1D or glucose tolerance despite increased pancreatic insulitis in pre-diabetic female NOD CNS1-/- mice. 31647813 2019
CUI: C0342942
Disease: Generalized obesity
Generalized obesity 		0.010 Biomarker disease BEFREE The ponies were grouped as having a) a normal to fleshy body status (BCS ≤7 and CNS ≤2; n = 10); b) having a high CNS, but without generalised obesity (BCS ≤7 and CNS ≥3; n = 11), or c) being obese (BCS ≥8 and CNS ≥1; n = 5). 31339945 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.010 Biomarker disease BEFREE In the CNS-1 GBM rat animal model SIXAC was found to reduce edema volume ratio (8.8 ± 1.9 vs. 4.9 ± 1, <i>p</i> < 0.04) and increase median survival (16 vs. 18.5 days, <i>p</i> < 0.02 by Log rank Mental-Cox test). 30619047 2018
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.010 Biomarker disease BEFREE In the CNS-1 GBM rat animal model SIXAC was found to reduce edema volume ratio (8.8 ± 1.9 vs. 4.9 ± 1, <i>p</i> < 0.04) and increase median survival (16 vs. 18.5 days, <i>p</i> < 0.02 by Log rank Mental-Cox test). 30619047 2018
CUI: C0017638
Disease: Glioma
Glioma 		0.030 Biomarker disease BEFREE Overexpression of a transmembrane isoform of neural cell adhesion molecule alters the invasiveness of rat CNS-1 glioma. 9581848 1998
CUI: C0017638
Disease: Glioma
Glioma 		0.030 Biomarker disease BEFREE To study the relationship between astrocytes and tumor cells, the CNS-1 rodent glioma cell line was used. 23695515 2013
CUI: C0017638
Disease: Glioma
Glioma 		0.030 Biomarker disease BEFREE A rat glioma model, CNS-1, with invasive characteristics similar to those of human gliomas: a comparison to 9L gliosarcoma. 7760095 1994
CUI: C0206726
Disease: gliosarcoma
gliosarcoma 		0.010 Biomarker disease BEFREE Comparisons of CNS-1 to 9L gliosarcoma tumor were made. 7760095 1994