TTC4, tetratricopeptide repeat domain 4, 7268

N. diseases: 32; N. variants: 1
Disease: Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 Biomarker group BEFREE Increased glutamate uptake in astrocytes via propentofylline results in increased tumor cell apoptosis using the CNS-1 glioma model. 23695515 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 AlteredExpression group BEFREE We also see increased TTC4 expression in a variety of tumour lines derived from other tissues. 18320024 2008
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 Biomarker group BEFREE We demonstrate that treatment with hsFlt3L leads to inhibition of tumor growth and significantly increased life span of animals implanted with syngeneic CNS-1 glioma cells. 15564139 2004
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 Biomarker group BEFREE Other members of this gene family have been implicated in tumorigenesis suggesting that TTC4 may represent a breast cancer tumor suppressor gene. 10639601 2000
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 Biomarker group BEFREE TTC4, a novel candidate tumor suppressor gene at 1p31 is often mutated in malignant melanoma of the skin. 11126369 2000
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 Biomarker group BEFREE To evaluate whether CpG-ODNs can induce rejection of established tumors, Lewis rats were inoculated intracerebrally with syngeneic CNS-1 glioma cells and subsequently injected with CpG-ODNs into the tumor bed. 10873101 2000
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 Biomarker group BEFREE Comparisons of CNS-1 to 9L gliosarcoma tumor were made. 7760095 1994