C5, complement C5, 727

N. diseases: 129; N. variants: 20
Disease: Gaucher Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017205
Disease: Gaucher Disease
Gaucher Disease 		0.020 Biomarker disease BEFREE Recently, we uncovered an unexpected link between the C5a and C5a receptor 1 (C5aR1) axis and the accumulation of GL1 in experimental and clinical GD. 29478824 2018
CUI: C0017205
Disease: Gaucher Disease
Gaucher Disease 		0.020 Biomarker disease BEFREE Here we show that activation of complement C5a and C5a receptor 1 (C5aR1) controls GC accumulation and the inflammatory response in experimental and clinical Gaucher disease. 28225753 2017