Adenocarcinoma of lung (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The expression of napsin A is common in thyroid tumors and the combined expression of napsin A and TTF-1 in a metastatic thyroid carcinoma is a cause for concern due to chances of misdiagnosis as lung adenocarcinoma.
|
31788765 |
2020 |
Adenocarcinoma of lung (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we compared the genome-wide distributions of TTF-1 binding regions and the transcriptional programs regulated by TTF-1 between NCI-H209 (H209), a human SCLC cell line, and NCI-H441 (H441), a human LADC cell line, using chromatin immunoprecipitation-sequencing (ChIP-seq) and RNA-sequencing (RNA-seq).
|
31782890 |
2020 |
Adenocarcinoma of lung (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
SOX10, GATA3, GCDFP15, Androgen Receptor, and Mammaglobin for the Differential Diagnosis Between Triple-negative Breast Cancer and TTF1-negative Lung Adenocarcinoma.
|
30628926 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
The receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a transcriptional target of the lineage-survival oncogene NKX2-1/TTF-1 in lung adenocarcinomas.
|
30894682 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The lung lineage master regulator gene, Thyroid Transcription Factor-1 (TTF-1, also known as NKX2-1), is used as a marker by pathologists to identify lung adenocarcinomas since TTF-1 is expressed in 60 ~ 70% of lung ADs.
|
31142791 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Primary lung adenocarcinomas expressed TTF-1 in 90% and napsin A in 84% of the cases, whereas 10% were positive for p63, 7% for CDX2, 2% for CK20, and 2% for GATA3.
|
30389437 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
TTF-1-positive lung adenocarcinoma patients had longer overall survival (OS) than those who were TTF-1 negative (19.3 vs. 5.8 months, p < 0.001).
|
31196060 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Immunocytochemistry in a 78-year-old man diagnosed as having systemic metastatic cancer of unknown primary origin revealed atypical cells positive for napsin A and TTF-1, suggesting adenocarcinoma of the lung.
|
31653481 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
REG4, an important regulator of gastro-intestinal carcinogenesis, was highly expressed in KRAS mutant lung adenocarcinoma with low expression of TTF-1 (KC subtype).
|
31428934 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
TTF1 expression is an independent predictor of survival of patients with advanced lung adenocarcinoma.
|
30348718 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
TTF-1 and napsin A for lung adenocarcinoma, p40 for squamous lung cancer, GATA3 and mammaglobin for breast cancer, or synaptophysin and chromogranin A for neuroendocrine tumors).
|
30354850 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
An immunohistochemical panel of calretinin, WT1, BEREP4, MOC31, and TTF1 confirmed the diagnosis of primary lung adenocarcinoma.
|
30927189 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
TTF-1 and napsin A had sensitivities of 99.0% and 91.9%, respectively, positive predictive values (PPVs) of 90.8% and 90.3%, respectively, and accuracies of 91.0% for adenocarcinoma of the lung.
|
31206846 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
The Incidence of Labelling of Non-Lung Adenocarcinomas With Antibodies Against TTF-1 and Diagnostic Implications.
|
31135446 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We investigate the molecular mechanisms underlying the functional connection between EGFR and TTF-1/Nkx2.1 gene expression in lung adenocarcinoma.
|
30314701 |
2018 |
Adenocarcinoma of lung (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We found that 19 (68%) of the 28 KRAS-mutant lung adenocarcinomas were differentiated tumors expressing thyroid transcription factor‑1 (TTF‑1) and E-cadherin.
|
29658609 |
2018 |
Adenocarcinoma of lung (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
All metastatic lung adenocarcinomas were positive for TTF-1 and TPO negative.
|
29508480 |
2018 |
Adenocarcinoma of lung (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We investigated the expression of napsin A, TTF1, SPA and CK7 in primary lung adenocarcinoma (ADC) and compared antibody specificity and sensitivity.
|
29956575 |
2018 |
Adenocarcinoma of lung (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our study highlights (1) the morphological diversity of SMARCA4-deficient lung adenocarcinoma, (2) the consistent absence of expression of TTF1 in the presence of expression of HepPar-1, (3) absence of EGFR driver mutations, and (4) frequent inactivating SMARCA4 mutations as underlying mechanism of the observed SMARCA4 protein loss.
|
28555282 |
2017 |
Adenocarcinoma of lung (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In 40 effusion smears from lung adenocarcinoma, the expression of the E-cadherin, a-catenin, Thyroid Transcription Factor (TTF-1), Epidermal Growth Factor Receptor (EGFR), p53, caspase 9 and 3, Bax and Bcl-2 was examined by immunocytochemistry.
|
28285961 |
2017 |
Adenocarcinoma of lung (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Inverse correlation between galectin-4 and TTF-1 in lung adenocarcinoma.
|
28725929 |
2017 |
Adenocarcinoma of lung (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Prognostic impact of TTF-1 expression in patients with stage IV lung adenocarcinomas.
|
28625636 |
2017 |
Adenocarcinoma of lung (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that the novel non-transcriptional function of TTF-1 identified in this study may contribute to lung adenocarcinoma development by conferring tolerance to DNA RS, which is known to be inherently elicited by activation of various oncogenes.
|
28192407 |
2017 |
Adenocarcinoma of lung (disorder)
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Inactivating mutations and hypermethylation of the NKX2-1/TTF-1 gene in non-terminal respiratory unit-type lung adenocarcinomas.
|
28677170 |
2017 |
Adenocarcinoma of lung (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
In summary, this study provides evidence that TTF-1 may reprogram lung cancer secreted proteome into an antiangiogenic state, offering a novel basis to account for the long-standing observation of favorable prognosis associated with TTF-1(+) lung adenocarcinomas.
|
26912193 |
2016 |