Disease: Cystic Fibrosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.100 AlteredExpression disease BEFREE Increased mRNA levels of IL1B, SPDEF, and ERN2 were associated with increased MUC5B and MUC5AC expression in the distal airways of excised CF lungs. 31524632 2019
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.100 Biomarker disease BEFREE The authors demonstrated that IL-1α and IL-1β stimulated non-CF human bronchial epithelial (HBE) cells to upregulate and secrete both MUC5B and MUC5AC in a dose-dependent manner, an effect that was neutralized by the inhibition of the IL-1α/IL-1β receptor (IL-1R1). 31524633 2019
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.100 Biomarker disease BEFREE Quantitative proteomics of BAL from CF and non-CF pairs demonstrated a mucoinflammatory signature in the CF lung dominated by Muc5B and neutrophil chemoattractants and products. 29327941 2018
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.100 Biomarker disease BEFREE MUC5AC sheets also accumulated in CF airways overlying MUC5B strands. 28607090 2017
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.100 Biomarker disease BEFREE Defective postsecretory maturation of MUC5B mucin in cystic fibrosis airways. 28352653 2017
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.100 Biomarker disease BEFREE In contrast, MUC5B D-domains were modified by neutrophil elastase, a protease commonly found in CF sputum, demonstrating that proteolytic degradation of MUC5B is an extracellular event in CF sputum. 26993521 2016
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.100 Biomarker disease BEFREE In addition, while the number of goblet cells expressing MUC5AC was similar in CF and non-CF regenerated epithelia, the number of MUC5B-immunopositive goblet cells was lower in CF grafts. 17186573 2007
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.100 AlteredExpression disease BEFREE Moreover, MUC5B expression was higher in NP epithelia from CF patients than in bilateral NP and healthy NM. 16630149 2006
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.100 Biomarker disease BEFREE We conclude that the vol/vol concentration of MUC5AC and MUC5B are decreased in the CF airways relative to normal mucus. 14988081 2004
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.100 Biomarker disease BEFREE Alterations in antibacterial peptide function, as well as the increased mucin expression and secretion (MUC 5AC and MUC 5B), are important biochemical factors responsible for the propensity for infection in CF airways. 12297057 2002
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.100 AlteredExpression disease BEFREE No remarkable differences were observed in the expression patterns of MUC5B or MUC7 between CF (n = 7) and non-CF (n = 10) bronchial samples. 9651178 1998
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.100 AlteredExpression disease BEFREE We compared expression levels of three mucin genes, MUC1, MUC2, and MUC5/5AC, known to be expressed in the respiratory tract of CF, allergic rhinitis, and normal individuals. 9685530 1998