C5AR1, complement C5a receptor 1, 728

N. diseases: 179; N. variants: 2
Disease: IGA Glomerulonephritis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis 		0.030 Biomarker disease BEFREE Blocking the C5a-C5aR1 axis resulted in a decrease in the albumin-to-creatinine ratio, and the attenuation of kidney damage in IgAN and RSV-IgAN mice might be partly attributed to the inhibition of Th cell and cytokine dysfunction. 31134161 2019
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis 		0.030 Biomarker disease BEFREE Targeting C3a/C5a receptors inhibits human mesangial cell proliferation and alleviates immunoglobulin A nephropathy in mice. 28295247 2017
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis 		0.030 AlteredExpression disease BEFREE Renal C3a and C5a deposition and C3aR and C5aR expression increased with increasing grades of renal pathology in IgAN patients. 24327134 2014