C5AR1, complement C5a receptor 1, 728

N. diseases: 179; N. variants: 2
Disease: Renal fibrosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0151650
Disease: Renal fibrosis
Renal fibrosis 		0.030 Biomarker disease BEFREE In this study C5aR1-/- and C5aR2-/- mice were compared to the wild type in a renal IRI model leading to renal fibrosis. 29935951 2018
CUI: C0151650
Disease: Renal fibrosis
Renal fibrosis 		0.030 AlteredExpression disease BEFREE In unilateral ureteral obstruction (UUO)-induced kidney fibrosis, the expression of C5aR and C5L2 increased similarly and gradually as fibrosis progressed and was particularly prominent in injured dilated tubules. 28903945 2018
CUI: C0151650
Disease: Renal fibrosis
Renal fibrosis 		0.030 Biomarker disease BEFREE This study investigated the role of C5 in the development of renal tubulointerstitial fibrosis by (1) induction of renal fibrosis in wild-type and C5(-/-) mice by unilateral ureteral ligation (UUO) and (2) investigation of the effects of a C5a receptor antagonist (C5aRA) in UUO. 17389734 2007