C5AR1, complement C5a receptor 1, 728

N. diseases: 179; N. variants: 2
Disease: Fulminant hepatitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0302809
Disease: Fulminant hepatitis
Fulminant hepatitis 		0.030 Biomarker disease BEFREE Treatment with the C5a receptor antagonist (C5aRa) diminished the differences in inflammatory responses and liver injury between MHV-infected wild-type and Msr1<sup>-/-</sup> mice, suggesting that C5a-induced pro-inflammatory response plays a critical role in the Msr1-mediated regulation of FH pathogenesis. 29154963 2018
CUI: C0302809
Disease: Fulminant hepatitis
Fulminant hepatitis 		0.030 Biomarker disease BEFREE Administration of antagonists against C5aR or TNF-α ameliorated MHV-3-induced FH. 25200905 2015
CUI: C0302809
Disease: Fulminant hepatitis
Fulminant hepatitis 		0.030 Biomarker disease BEFREE C5a/C5aR pathway is essential for the pathogenesis of murine viral fulminant hepatitis by way of potentiating Fgl2/fibroleukin expression. 24604562 2014