C5AR1, complement C5a receptor 1, 728

N. diseases: 179; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.300 Biomarker disease CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136 2014
CUI: C0036981
Disease: Endotoxic shock
Endotoxic shock 		0.300 Biomarker phenotype CTD_human Disruption of the C5a receptor gene increases resistance to acute Gram-negative bacteremia and endotoxic shock: opposing roles of C3a and C5a. 18063050 2008
CUI: C0036983
Disease: Septic Shock
Septic Shock 		0.300 Biomarker phenotype CTD_human Disruption of the C5a receptor gene increases resistance to acute Gram-negative bacteremia and endotoxic shock: opposing roles of C3a and C5a. 18063050 2008
CUI: C0600327
Disease: Toxic Shock Syndrome
Toxic Shock Syndrome 		0.300 Biomarker disease CTD_human Disruption of the C5a receptor gene increases resistance to acute Gram-negative bacteremia and endotoxic shock: opposing roles of C3a and C5a. 18063050 2008
CUI: C0243026
Disease: Sepsis
Sepsis 		0.290 Biomarker disease BEFREE We recently discovered that C5aR1 exacerbates the course of the disease, revealing a downside of complement in <i>Nme</i> sepsis. 31274379 2019
CUI: C0243026
Disease: Sepsis
Sepsis 		0.290 Biomarker disease BEFREE MEDI7814 has therapeutic potential for the treatment of acute inflammatory conditions in which both C5a receptors may mediate inflammation, such as sepsis or renal ischemia-reperfusion injury. 28952876 2018
CUI: C0243026
Disease: Sepsis
Sepsis 		0.290 Biomarker disease BEFREE Together, these data emphasize the role of complement (C5a) and C5a receptors (C5aR1, C5aR2), as well as extracellular histones in events that lead to cardiac dysfunction of sepsis (septic cardiomyopathy). 29914696 2018
CUI: C0243026
Disease: Sepsis
Sepsis 		0.290 Biomarker disease BEFREE C5a, C5aR, and NF-κB, which were shown to be the key molecules in brain injury pathogenesis in sepsis, might also be utilized as potential targets for future treatment trials of septic encephalopathy. 29232196 2018
CUI: C0243026
Disease: Sepsis
Sepsis 		0.290 Biomarker disease BEFREE Together, our findings demonstrate that C5aR1 drives the pathophysiology associated with meningococcal sepsis and provides a promising target for adjunctive therapy.<b>IMPORTANCE</b> The devastating consequences of <i>N. meningitidis</i> sepsis arise due to the rapidly arising and self-propagating inflammatory response that mobilizes antibacterial defenses but also drives the immunopathology associated with meningococcemia. 29362231 2018
CUI: C0243026
Disease: Sepsis
Sepsis 		0.290 Biomarker disease BEFREE Our studies, using in vivo and in vitro models, have demonstrated that C5a and its receptors (C5aR1 and C5aR2) play key roles in cardiac dysfunction developing during sepsis. 27931779 2017
CUI: C0243026
Disease: Sepsis
Sepsis 		0.290 Biomarker disease BEFREE Complement 5a (C5a) has been implicated in the pathogenesis of sepsis by inducing the functional impairment of neutrophils; however, the utility of C5a receptors (C5aRs; C5aR and C5L2) as biomarkers for the management of sepsis is uncertain. 25726869 2016
CUI: C0243026
Disease: Sepsis
Sepsis 		0.290 Biomarker disease RGD The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis. 18648551 2008
CUI: C0243026
Disease: Sepsis
Sepsis 		0.290 GeneticVariation disease BEFREE During experimental sepsis in rodents after cecal ligation and puncture (CLP), excessive C5a is generated, leading to interactions with C5aR, loss of innate immune functions of neutrophils, and lethality. 15784721 2005
CUI: C0243026
Disease: Sepsis
Sepsis 		0.290 ModifyingMutation disease RGD Neutrophil C5a receptor and the outcome in a rat model of sepsis. 12897064 2003
CUI: C0243026
Disease: Sepsis
Sepsis 		0.290 AlteredExpression disease BEFREE These results demonstrate the expression of C3aR and C5aR by cells endogenous to the lung, and, given the participation of bronchial epithelial and smooth muscle cells in the pathology of diseases such as sepsis and asthma, the data suggest a role for these receptors during lung inflammation. 11160252 2001
CUI: C0004096
Disease: Asthma
Asthma 		0.270 AlteredExpression disease BEFREE RSV enhanced lung damage, airway hyperresponsiveness, and C5aR expressions in asthma mice, while C5aRA alleviated these pathologic changes. 29123203 2017
CUI: C0004096
Disease: Asthma
Asthma 		0.270 Biomarker disease RGD Use of monoclonal antibodies to assess expression of anaphylatoxin receptors in rat and murine models of lung inflammation. 17544263 2007
CUI: C0004096
Disease: Asthma
Asthma 		0.270 Biomarker disease LHGDN Contribution of anaphylatoxins to allergic inflammation in human lungs. 16301808 2005
CUI: C0004096
Disease: Asthma
Asthma 		0.270 GeneticVariation disease BEFREE To determine whether genetic variations in the genes of the complement system affect susceptibility to BA, we screened single nucleotide polymorphisms (SNPs) in C3, C5, the C3a receptor gene (C3AR1), and the C5a receptor gene (C5R1) and performed association studies in the Japanese population. 15278436 2004
CUI: C0004096
Disease: Asthma
Asthma 		0.270 GeneticVariation disease BEFREE The aim of this study was to screen for novel polymorphisms in the C5R1 gene and to determine whether any identified polymorphisms are associated with asthma and/or atopy and whether they are functional. 15144465 2004
CUI: C0004096
Disease: Asthma
Asthma 		0.270 AlteredExpression disease LHGDN Complement factors c3a, c4a, and c5a in chronic obstructive pulmonary disease and asthma. 15039137 2004
CUI: C0004096
Disease: Asthma
Asthma 		0.270 AlteredExpression disease BEFREE These results demonstrate the expression of C3aR and C5aR by cells endogenous to the lung, and, given the participation of bronchial epithelial and smooth muscle cells in the pathology of diseases such as sepsis and asthma, the data suggest a role for these receptors during lung inflammation. 11160252 2001
CUI: C0004096
Disease: Asthma
Asthma 		0.270 Biomarker disease BEFREE Blockade of the C5a receptor rendered human monocytes unable to produce IL-12, mimicking blunted IL-12 production by macrophages from C5-deficient mice and providing a mechanism for the regulation of susceptibility to asthma by C5. 10973279 2000
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 		0.240 AlteredExpression disease BEFREE These results indicate that similar to SOD1 transgenic animals, local complement activation and increased expression of C5aR1 may contribute to motor neuron death and neuromuscular junction denervation in the TDP-43<sup>Q331K</sup> mouse ALS model. 29859100 2018
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 		0.240 Biomarker disease BEFREE Importantly, genetic or pharmacological blockage of C5aR1 improves motor performance and reduces disease pathology in hSOD1<sup>G93A</sup> rodent models of ALS. 28571586 2017