SPANXA2, SPANX family member A2, 728712

N. diseases: 30; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.030 AlteredExpression disease BEFREE Based on these data, we conclude that SPAN-Xb is a novel member of the family of cancer/testis antigens aberrantly expressed by, and capable of inducing, immune responses in patients with multiple myeloma and other hematologic malignancies. 12393489 2003
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia 		0.010 AlteredExpression disease BEFREE In the present study, we have used a pair of sequence-specific primers in reverse transcription-polymerase chain reaction (RT-PCR) and sequence analysis to demonstrate that the X-linked gene encoding SPAN-Xb is expressed in multiple myeloma and other hematologic malignancies such as chronic lymphocytic leukemia (CLL), chronic myeloid leukemia (CML), and acute myeloid leukemia (AML). 12393489 2003
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.010 AlteredExpression disease BEFREE In the present study, we have used a pair of sequence-specific primers in reverse transcription-polymerase chain reaction (RT-PCR) and sequence analysis to demonstrate that the X-linked gene encoding SPAN-Xb is expressed in multiple myeloma and other hematologic malignancies such as chronic lymphocytic leukemia (CLL), chronic myeloid leukemia (CML), and acute myeloid leukemia (AML). 12393489 2003
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.010 AlteredExpression disease BEFREE In the present study, we have used a pair of sequence-specific primers in reverse transcription-polymerase chain reaction (RT-PCR) and sequence analysis to demonstrate that the X-linked gene encoding SPAN-Xb is expressed in multiple myeloma and other hematologic malignancies such as chronic lymphocytic leukemia (CLL), chronic myeloid leukemia (CML), and acute myeloid leukemia (AML). 12393489 2003
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms 		0.010 AlteredExpression group BEFREE In the present study, we have used a pair of sequence-specific primers in reverse transcription-polymerase chain reaction (RT-PCR) and sequence analysis to demonstrate that the X-linked gene encoding SPAN-Xb is expressed in multiple myeloma and other hematologic malignancies such as chronic lymphocytic leukemia (CLL), chronic myeloid leukemia (CML), and acute myeloid leukemia (AML). 12393489 2003
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.040 Biomarker group BEFREE The data herein suggest that the SPAN-X protein may be a useful target in cancer immunotherapy. 14734458 2004
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 Biomarker group BEFREE The data herein suggest that the SPAN-X protein may be a useful target in cancer immunotherapy. 14734458 2004
CUI: C0025202
Disease: melanoma
melanoma 		0.020 Biomarker disease BEFREE Immunoperoxidase labeling of melanoma cells and tissue sections demonstrated SPAN-X protein localization in the nucleus, cytoplasm, or both. 14734458 2004
CUI: C0037286
Disease: Skin Neoplasms
Skin Neoplasms 		0.010 Biomarker group BEFREE Significantly, the incidence of SPAN-X-positive immunostaining was greatest in the more aggressive skin tumors, particularly in distant, nonlymphatic metastatic melanomas. 14734458 2004
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.040 Biomarker group BEFREE Human sperm protein associated with the nucleus on the X chromosome (SPANX) genes comprise a gene family with five known members (SPANX-A1, -A2, -B, -C, and -D), encoding cancer/testis-specific antigens that are potential targets for cancer immunotherapy. 14973187 2004
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 Biomarker group BEFREE Human sperm protein associated with the nucleus on the X chromosome (SPANX) genes comprise a gene family with five known members (SPANX-A1, -A2, -B, -C, and -D), encoding cancer/testis-specific antigens that are potential targets for cancer immunotherapy. 14973187 2004
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.030 AlteredExpression disease BEFREE In this study, we determined the mechanisms regulating SPAN-Xb expression in MM. 16187275 2006
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 Biomarker group BEFREE Tumor cells were treated with 5-azacytidine and a panel of cytokines were used to determine their ability to induce SPAN-Xb expression. 16187275 2006
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.020 GeneticVariation disease BEFREE We speculate that the predisposition to prostate cancer in X-linked families is an example of a genomic disease caused by a specific architecture of the SPANX gene cluster. 16251457 2005
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.020 GeneticVariation disease BEFREE We speculate that the predisposition to prostate cancer in X-linked families is an example of a genomic disease caused by a specific architecture of the SPANX gene cluster. 16251457 2005
CUI: C0036631
Disease: Seminoma
Seminoma 		0.010 AlteredExpression disease BEFREE In conclusion, these data suggest that the SpanX protein family is not exclusively expressed post-meiotically and that seminomas and embryonal carcinomas may originate from SpanX-positive carcinoma-in-situ cell. 16390498 2006
CUI: C0206659
Disease: Embryonal Carcinoma
Embryonal Carcinoma 		0.010 AlteredExpression disease BEFREE In conclusion, these data suggest that the SpanX protein family is not exclusively expressed post-meiotically and that seminomas and embryonal carcinomas may originate from SpanX-positive carcinoma-in-situ cell. 16390498 2006
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.030 Biomarker disease BEFREE SPAN-Xb is a novel cancer-testis antigen in multiple myeloma. 17036333 2006
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.020 Biomarker phenotype BEFREE The function of SpanX proteins is unknown, evidence is accumulating to suggest their involvement in tumorigenesis. 17204091 2006
CUI: C0205851
Disease: Germ cell tumor
Germ cell tumor 		0.010 AlteredExpression disease BEFREE Expression of SpanX mRNA in testicular germ cell tumors. 17204091 2006
CUI: C1336708
Disease: Testicular Germ Cell Tumor
Testicular Germ Cell Tumor 		0.010 AlteredExpression disease BEFREE The results showed that SpanX mRNA is present in TGCT, confirming transcriptional activity of these genes in such tumors. 17204091 2006
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.020 GeneticVariation disease BEFREE Mutational analysis of SPANX genes in families with X-linked prostate cancer. 17373721 2007
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.020 GeneticVariation disease BEFREE Mutational analysis of SPANX genes in families with X-linked prostate cancer. 17373721 2007
CUI: C0153594
Disease: Malignant neoplasm of testis
Malignant neoplasm of testis 		0.010 Biomarker disease BEFREE The SPANX genes encode cancer-testis (CT) specific antigens. 17373721 2007
CUI: C0025202
Disease: melanoma
melanoma 		0.020 Biomarker disease BEFREE A statistical significant difference for a particular class of SPANX-C gene was found comparing patients with melanoma and controls (P=0.011). 18626316 2008