|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
In addition, certain members of CTAs, including Piwil2, DNAJB8, CT45A1, MAGE-A, GAGE, and SPANX, are implicated in the initiation or maintenance, of cancer stem-like cells, promoting tumorigenesis and malignant progression.
|
25506890 |
2015 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
In addition, certain members of CTAs, including Piwil2, DNAJB8, CT45A1, MAGE-A, GAGE, and SPANX, are implicated in the initiation or maintenance, of cancer stem-like cells, promoting tumorigenesis and malignant progression.
|
25506890 |
2015 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
However, 3 cancer/testis antigen genes (PAGE4, SCP-1, and SPANX) and 3 clinicopathologic parameters (lymph node involvement, vessel cancer embolus, and tumor invasion depth) correlated significantly with liver metastasis of colorectal cancer (P < .05).
|
20010347 |
2010 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
However, 3 cancer/testis antigen genes (PAGE4, SCP-1, and SPANX) and 3 clinicopathologic parameters (lymph node involvement, vessel cancer embolus, and tumor invasion depth) correlated significantly with liver metastasis of colorectal cancer (P < .05).
|
20010347 |
2010 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Human sperm protein associated with the nucleus on the X chromosome (SPANX) genes comprise a gene family with five known members (SPANX-A1, -A2, -B, -C, and -D), encoding cancer/testis-specific antigens that are potential targets for cancer immunotherapy.
|
14973187 |
2004 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
The data herein suggest that the SPAN-X protein may be a useful target in cancer immunotherapy.
|
14734458 |
2004 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
The data herein suggest that the SPAN-X protein may be a useful target in cancer immunotherapy.
|
14734458 |
2004 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Human sperm protein associated with the nucleus on the X chromosome (SPANX) genes comprise a gene family with five known members (SPANX-A1, -A2, -B, -C, and -D), encoding cancer/testis-specific antigens that are potential targets for cancer immunotherapy.
|
14973187 |
2004 |
|
Multiple Myeloma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In this study, we determined the mechanisms regulating SPAN-Xb expression in MM.
|
16187275 |
2006 |
|
Multiple Myeloma
|
0.030 |
Biomarker
|
disease |
BEFREE |
SPAN-Xb is a novel cancer-testis antigen in multiple myeloma.
|
17036333 |
2006 |
|
Multiple Myeloma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Based on these data, we conclude that SPAN-Xb is a novel member of the family of cancer/testis antigens aberrantly expressed by, and capable of inducing, immune responses in patients with multiple myeloma and other hematologic malignancies.
|
12393489 |
2003 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
SPANXA suppressed the invasion and metastasis of lung cancer cells in vitro and in vivo.
|
27323831 |
2016 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In addition, certain members of CTAs, including Piwil2, DNAJB8, CT45A1, MAGE-A, GAGE, and SPANX, are implicated in the initiation or maintenance, of cancer stem-like cells, promoting tumorigenesis and malignant progression.
|
25506890 |
2015 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
However, 3 cancer/testis antigen genes (PAGE4, SCP-1, and SPANX) and 3 clinicopathologic parameters (lymph node involvement, vessel cancer embolus, and tumor invasion depth) correlated significantly with liver metastasis of colorectal cancer (P < .05).
|
20010347 |
2010 |
|
melanoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
A statistical significant difference for a particular class of SPANX-C gene was found comparing patients with melanoma and controls (P=0.011).
|
18626316 |
2008 |
|
Malignant neoplasm of prostate
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Mutational analysis of SPANX genes in families with X-linked prostate cancer.
|
17373721 |
2007 |
|
Prostate carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Mutational analysis of SPANX genes in families with X-linked prostate cancer.
|
17373721 |
2007 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The function of SpanX proteins is unknown, evidence is accumulating to suggest their involvement in tumorigenesis.
|
17204091 |
2006 |
|
Malignant neoplasm of prostate
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We speculate that the predisposition to prostate cancer in X-linked families is an example of a genomic disease caused by a specific architecture of the SPANX gene cluster.
|
16251457 |
2005 |
|
Prostate carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We speculate that the predisposition to prostate cancer in X-linked families is an example of a genomic disease caused by a specific architecture of the SPANX gene cluster.
|
16251457 |
2005 |
|
melanoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Immunoperoxidase labeling of melanoma cells and tissue sections demonstrated SPAN-X protein localization in the nucleus, cytoplasm, or both.
|
14734458 |
2004 |
|
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In conclusion, we found that SPANX-C expression could play a role in tumor progression of uveal melanoma.
|
31072624 |
2019 |
|
Uveal melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, we found that SPANX-C expression could play a role in tumor progression of uveal melanoma.
|
31072624 |
2019 |
|
metastatic intraocular melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunoexpression of SPANX-C in metastatic uveal melanoma.
|
31072624 |
2019 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
SPANXA suppressed the invasion and metastasis of lung cancer cells in vitro and in vivo.
|
27323831 |
2016 |