|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Levels of miR-129-5p were low in breast cancer tissues. miR-129-5p down-regulation correlated with advanced clinical stage and poor prognosis in patients with breast cancer. miR-129-5p expression negatively correlated with Twist1 and Snail expression.
|
26460733 |
2015 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Clinically, miR-373 is negatively associated with TXNIP and positively associated with HIF1α and TWIST, and activation of the miR-373-TXNIP-HIF1α-TWIST signaling axis is correlated with a worse outcome in patients with breast cancer.
|
26196741 |
2015 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Unexpectedly, we observed that BRMS1 downregulates not only TWIST1 but also Snail expression, thereby inhibiting breast cancer cell invasion.
|
26520789 |
2015 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In addition, 296 human breast cancer specimens were classified according to the presence of the fibrous or adipose stroma and analyzed by immunohistochemistry for the expression of estrogen and progesterone receptors, human epidermal growth factor receptor 2, antigen Ki-67, N-cadherin, Twist-related protein 1 (TWIST1), high-mobility group AT-hook 2, TGFβ, and S100 calcium-binding protein A4 using tissue microarray.
|
26285644 |
2015 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Mice with germ-line Twist1 knockout are embryonic lethal, while adult mice with inducible Twist1 knockout have no obvious health problems, suggesting that Twist1 is a viable therapeutic target for the inhibition of invasion and metastasis of breast cancer in adult patients.
|
25892968 |
2015 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The aim of the study was to examine the association of EMT markers SLUG and TWIST with clinicopathological data and the possibility of using these proteins as prognostic markers of breast cancer.
|
26124343 |
2015 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Special AT-rich sequence-binding protein-1 participates in the maintenance of breast cancer stem cells through regulation of the Notch signaling pathway and expression of Snail1 and Twist1.
|
25586771 |
2015 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Enhanced expression of genes associated with a mesenchymal transition includes ZEB1/2, TWIST, and FOXC1. miRNAs are known regulators of gene expression and altered miRNA expression is known to enhance EMT in breast cancer.
|
26062653 |
2015 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
RNA-based TWIST1 inhibition via dendrimer complex to reduce breast cancer cell metastasis.
|
25759817 |
2015 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Although NCOA1 is known to promote breast cancer metastasis through working with multiple transcription factors to upregulate the expression of Twist1, ITGA5, CSF-1, SDF1 and CXCR4, the role of NCOA1 in breast tumor angiogenesis has not been investigated.
|
26287601 |
2015 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that a combined SRC-1/Twist1 expression status could improve the prognostic judgment for breast cancer patients.
|
24719557 |
2014 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Our study suggests that Sox5 transactivates Twist1 expression and plays an important role in the regulation of breast cancer progression.
|
24607904 |
2014 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Taken together, our results suggest that TRIM29 acts as a tumor suppressor in breast cancer through its ability to inhibit TWIST1 and suppress EMT.
|
24950909 |
2014 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Decreased levels of LARP7 and 7SK snRNA redistribute P-TEFb to the transcriptionally active super elongation complex, resulting in P-TEFb activation and increased transcription of EMT transcription factors, including Slug, FOXC2, ZEB2, and Twist1, to promote breast cancer EMT, invasion, and metastasis.
|
25053741 |
2014 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Consistent with the reduced TWIST1 levels in breast cancer, reexpression of miR-720 upregulated epithelial markers (E-cadherin and β-catenin) and downregulated mesenchymal markers (N-cadherin, fibronectin, vimentin and matrix metalloproteinase-2).
|
24085799 |
2014 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
To address this question, human osteotropic MDA-MB-231/B02 breast cancer cells were stably transfected with a Tet-inducible vector encoding for TWIST1, whose expression was specifically repressed in the presence of doxycycline (dox).
|
24619707 |
2014 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
High ALDH1 expression (ALDH1high) and nuclear TWIST localization (TWISTnuc) on CTCs was confirmed in more patients with metastatic than early breast cancer (80% vs. 30.8%, respectively; p = 0.009).
|
25182808 |
2014 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Sox2 regulates the invasiveness of BC cells via a mechanism that is dependent on Twist1 and the transcriptional status of Sox2.
|
23815808 |
2013 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
These results demonstrate that TWIST/NuRD represses ERα expression in breast cancer cells.
|
22457607 |
2012 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
ARTEMIN promotes de novo angiogenesis in ER negative mammary carcinoma through activation of TWIST1-VEGF-A signalling.
|
23185544 |
2012 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study was to investigate whether TWIST1 expression predicts disease progression in a large breast cancer cohort with long-term clinical follow-up, and to reveal the biology related to TWIST1 mediated disease progression.
|
22967435 |
2012 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Significantly, in breast carcinoma samples, SET8 expression is positively correlated with metastasis and the expression of TWIST and N-cadherin and negatively correlated with E-cadherin.
|
21983900 |
2012 |
|
Breast Carcinoma
|
0.200 |
PosttranslationalModification
|
disease |
BEFREE |
The objective of this study was to evaluate whether pyrosequencing promoter DNA in a panel of 12 breast cancer-related genes (APC, BRCA1, CCND2, CDH1, ESR1, GSTP1, HIN1, P16, RARβ, RASSF1, SFRP1 and TWIST) to measure the degree of methylation would lead to a useful serum-based marker of breast cancer.
|
22986510 |
2012 |
|
Breast Carcinoma
|
0.200 |
PosttranslationalModification
|
disease |
BEFREE |
Age-adjusted Cox proportional hazards models revealed that GSTP1, TWIST and RARβ methylation was significantly associated with higher breast cancer-specific mortality.
|
21837480 |
2012 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Translational control of TWIST1 expression in MCF-10A cell lines recapitulating breast cancer progression.
|
22266852 |
2012 |