|
Mammary Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In particular, recent evidence has linked increased expression of EMT markers such as TWIST1 and MMPs in breast tumors with increased immune infiltration in the TME.
|
31075939 |
2019 |
|
Mammary Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To determine the intrinsic role of Twist1 in EMT and breast cancer initiation, growth, and metastasis, we developed mouse models with an oncogene-induced mammary tumor containing wild-type (WT) <i>Twist1</i> or tumor cell-specific <i>Twist1</i> knockout (Twist1<sup>TKO</sup>).
|
29073077 |
2017 |
|
Mammary Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, Twist1 expression is negatively correlated with Foxa1 in the human breast tumors.
|
27524420 |
2017 |
|
Mammary Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
There is evidence to indicate that Twist expression plays a role in breast tumor formation and metastasis, but the role of Twist in dysregulating pathways that drive the metastatic cascade is unclear.
|
28086829 |
2017 |
|
Mammary Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Using a tethered dimer strategy, we successively assessed the ability of TWIST1 dimers to cooperate with an activated version of RAS in human mammary epithelial cell transformation, to provide mice with the ability to spontaneously develop breast tumors, and lastly to maintain a senescence program at a latent state in several breast cancer cell lines.
|
27237323 |
2016 |
|
Mammary Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The aim of this study was to assess correlation between CTCs and expression of EMT transcription factors TWIST1 and SLUG in breast tumor tissue.
|
26194471 |
2015 |
|
Mammary Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In summary, the regulation of ER by Twist could be an underlying mechanism for the loss of ER activity observed in breast tumors, and may contribute to the generation of hormone-resistant, ER-negative breast cancer.
|
22056872 |
2012 |
|
Mammary Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
SNAIL, SLUG, and TWIST expression were examined on a TMA containing 575 breast tumors using immunohistochemistry.
|
21796367 |
2012 |
|
Mammary Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Loss of estrogen receptor α (ERα) expression and gain of TWIST (TWIST1) expression in breast tumors correlate with increased disease recurrence and metastasis and poor disease-free survival.
|
22457607 |
2012 |
|
Mammary Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Both western blotting and immunohistochemistry staining showed that the expression of DLX4 and TWIST are correlated in most of breast tumors.
|
23091415 |
2012 |
|
Mammary Neoplasms
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel.
|
17332325 |
2007 |
|
Mammary Neoplasms
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Isolation and molecular profiling of bone marrow micrometastases identifies TWIST1 as a marker of early tumor relapse in breast cancer patients.
|
17785550 |
2007 |
|
Mammary Neoplasms
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer.
|
16322226 |
2005 |