|
Influenza
|
0.030 |
Biomarker
|
disease |
BEFREE |
(4) Local (IgA) and systemic (IgG) antibody productions against influenza virus hemagglutinin in mice surviving 3 weeks after infection were similar between wild-type and TRX Tg mice.
|
12008049 |
2002 |
|
Acute respiratory distress
|
0.010 |
Biomarker
|
disease |
BEFREE |
3,5,4'-Tri-O-acetylresveratrol attenuates seawater inhalation-induced acute respiratory distress syndrome via thioredoxin 1 pathway.
|
29512754 |
2018 |
|
Obsessive-Compulsive Disorder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
8-F2-isoprostane, thioredoxin and thioredoxin reductase levels in children with obsessive-compulsive disorder.
|
29927677 |
2018 |
|
Ductal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ductal carcinomas showed stronger cytoplasmic thioredoxin immunoreactivity than lobular ones.
|
15056229 |
2004 |
|
Hyperglycemia
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Hyperglycemia regulates thioredoxin-ROS activity through induction of thioredoxin-interacting protein (TXNIP) in metastatic breast cancer-derived cells MDA-MB-231.
|
17555594 |
2007 |
|
Auricular swelling
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Ear swelling after UVB irradiation was significantly reduced in TRX-transgenic mouse compared with wild-type mouse.
|
23328539 |
2014 |
|
Selenium deficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Selenium deficiency-induced thioredoxin suppression and thioredoxin knock down disbalanced insulin responsiveness in chicken cardiomyocytes through PI3K/Akt pathway inhibition.
|
28734787 |
2017 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Cancer cells adapt to their inherently increased oxidative stress through activation of the glutathione (GSH) and thioredoxin (TXN) systems.
|
29444979 |
2018 |
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Cancer cells adapt to their inherently increased oxidative stress through activation of the glutathione (GSH) and thioredoxin (TXN) systems.
|
29444979 |
2018 |
|
Ischemic stroke
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Ischemic stroke reduces Trx-1 activity via post-translational nitrative modulation in rats.
|
30447684 |
2018 |
|
Ischemic cardiomyopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ischemic Cardiomyopathy Affects the Thioredoxin System in the Human Myocardium.
|
30721734 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor sensitivity to cisplatin [cis-diamminedichloroplatinum (II)], but not to mitomycin C or doxorubicin, correlated with mRNA levels of TRX in cancer tissue.
|
8968078 |
1996 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cancer cells were found to release thioredoxin into the medium at rates between 1 to 2 pmole/10(6) cells/3 hours.
|
9042207 |
1997 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Cancer cells were found to release thioredoxin into the medium at rates between 1 to 2 pmole/10(6) cells/3 hours.
|
9042207 |
1997 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.070 |
Biomarker
|
disease |
BEFREE |
Adult T cell leukemia derived factor (ADF)/thioredoxin (Trx) is known to be an important intracellular antioxidant involved in a number of redox reactions such as ribonucleotide reductase (RNR) as well as of tyrosinase.
|
9475178 |
1998 |
|
Leukemia, T-Cell
|
0.060 |
Biomarker
|
disease |
BEFREE |
Adult T cell leukemia derived factor (ADF)/thioredoxin (Trx) is known to be an important intracellular antioxidant involved in a number of redox reactions such as ribonucleotide reductase (RNR) as well as of tyrosinase.
|
9475178 |
1998 |
|
Cataract
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thioredoxin (TRX)-1 and TRX-2 redox-regulatory genes were analyzed in the lens and some other tissues of the Emory mouse, a model for age-related human cataract.
|
10558869 |
1999 |
|
Uterine Fibroids
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Thioredoxin expression in uterine fibroids does not seem to be up-regulated, but changes in response to the endocrine conditions in a similar way to that observed in the myometrium.
|
10611262 |
2000 |
|
Carcinoma
|
0.050 |
Biomarker
|
group |
BEFREE |
Trx-1 transfection also caused a significant increase in the protein products of hypoxia-responsive genes, including vascular endothelial growth factor (VEGF) and nitric oxide synthase 2 in a number of different cell lines (MCF-7 human breast and HT29 human colon carcinomas and WEHI7.2 mouse lymphoma cells) under both normoxic and hypoxic conditions.
|
12208766 |
2002 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Thioredoxin is associated with proliferation, p53 expression and negative estrogen and progesterone receptor status in breast carcinoma.
|
15056229 |
2004 |
|
Pancreatic carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Thioredoxin is downstream of Smad7 in a pathway that promotes growth and suppresses cisplatin-induced apoptosis in pancreatic cancer.
|
15150118 |
2004 |
|
Malignant neoplasm of pancreas
|
0.030 |
Biomarker
|
disease |
BEFREE |
Thioredoxin is downstream of Smad7 in a pathway that promotes growth and suppresses cisplatin-induced apoptosis in pancreatic cancer.
|
15150118 |
2004 |
|
Autoimmune myocarditis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thioredoxin-1 ameliorates myosin-induced autoimmune myocarditis by suppressing chemokine expressions and leukocyte chemotaxis in mice.
|
15337697 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Thioredoxin (Trx), a small redox protein, is overexpressed in a number of tumors, however, its roles in tumor cells were not defined well.
|
15754001 |
2005 |
|
Hepatitis C
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TRX and TBP-2 mRNA levels in the liver before IFN therapy may predict the outcome of IFN therapy in patients with chronic serotype 1 HCV infection.
|
16685406 |
2006 |