|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tissue microarray of breast cancer patients and immunohistochemical method were used to analyze the role of Trx-1 in breast cancer metastasis.
|
30396169 |
2018 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Tissue microarray of breast cancer patients and immunohistochemical method were used to analyze the role of Trx-1 in breast cancer metastasis.
|
30396169 |
2018 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Peroxiredoxin-1 (Prdx1), a member of the thioredoxin (Txn) system, is overexpressed and correlates with poor prognosis in pancreatic cancer patients and can suppress Kras signaling through redox-mediated inhibition of ERK and AKT in lung and breast cancer.
|
29190947 |
2017 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to investigate the role of thioredoxin (Trx1) in the invasion and migration of breast cancer cells and to assess the strength of the association between high levels of Trx1 and thioredoxin reductase (TrxR1) expression with breast cancer patient survival.
|
26760912 |
2016 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We analysed the expression of the thioredoxin system in the MDA-MB-231 breast cancer cell line under conditions mimicking the tumor oxygen microenvironment.
|
22342720 |
2012 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our data provide a functional basis for Trx-1 and MMP-9 association in malignant breast cancer and identify Trx-1 and NF-κB as potentially druggable targets for reducing MMP-9 involvement in malignant behaviour.
|
21963718 |
2011 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Western blot analysis of different and paired breast tissues revealed consistent and preferential expression of Prx I and Trx1 protein in breast cancer tissue.
|
19566940 |
2009 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Thioredoxin is associated with proliferation, p53 expression and negative estrogen and progesterone receptor status in breast carcinoma.
|
15056229 |
2004 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Stable transfection of human breast carcinoma MCF-7 cells with human Trx-1 caused a significant increase in HIF-1alpha protein levels under both normoxic (20% oxygen) and hypoxic (1% oxygen) conditions.
|
12208766 |
2002 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that TRX expression is linked to the ER- and p53-dependent regulation of tumor growth in breast cancer.
|
11705859 |
2001 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Next, we examined the expression of TRX and p53 in breast cancer cell line MCF-7 cells after CDDP treatment or irradiation.
|
11163861 |
2000 |
|
Neoplasm Metastasis
|
0.390 |
GeneticVariation
|
phenotype |
BEFREE |
We previously reported a novel positive feedback loop between thioredoxin-1 (Trx-1) and S100P, which promotes the invasion and metastasis of colorectal cancer (CRC).
|
29383839 |
2018 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Tissue microarray of breast cancer patients and immunohistochemical method were used to analyze the role of Trx-1 in breast cancer metastasis.
|
30396169 |
2018 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Mutant or deleted thioredoxin motif in rhAGR2 was also unable to bind to rhVEGFA that led to the significant abolishment in the vessel formation, but partially affecting the aggressive process, implicating alternative mechanisms are required for AGR2-conferring metastasis.
|
29410027 |
2018 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
CTD_human |
Spotaneous metastasis model and experimental metastasis model combined with HE staining, immunohistochemistry were used to verify in vivo anti-metastatic effect of DATS as well as its regulation on thioredoxin.
|
30396169 |
2018 |
|
Neoplasm Metastasis
|
0.390 |
AlteredExpression
|
phenotype |
BEFREE |
The ratio of thioredoxin/Keap1 protein level in the normal (OR: 0.12; 95% CI: 0.02-0.83) or tumor tissue (OR: 0.17; 95% CI: 0.03-0.89) was a negative predictor for distant metastasis in CRC.
|
29053012 |
2017 |
|
Neoplasm Metastasis
|
0.390 |
AlteredExpression
|
phenotype |
BEFREE |
Conversely, suppression of Trx-1 expression decreased cell invasion and metastasis in vitro and in vivo.
|
28483515 |
2017 |
|
Neoplasm Metastasis
|
0.390 |
AlteredExpression
|
phenotype |
BEFREE |
The results indicated that the expression levels of ADAMTSL4 and TXN were highly correlated with the lymph node and distant metastasis (P<0.05) in NPC patients.
|
28107202 |
2017 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Thioredoxin, a prometastasis factor, is negatively regulated by TIP30 and plays an essential role during the process of HCC metastasis.
|
26752068 |
2016 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Analysis of 25 independent cohorts with 5910 patients showed that Trx1 and TrxR1 were both associated with a poor patient prognosis in terms of overall survival, distant metastasis free survival and disease free survival.
|
26760912 |
2016 |
|
Neoplasm Metastasis
|
0.390 |
AlteredExpression
|
phenotype |
LHGDN |
Expression of VEGF and Ref-1 is associated with Trx-1 overexpression, which is related to a poor prognosis in patients with liver metastases from colorectal cancer.
|
17949784 |
2008 |
|
Malignant neoplasm of breast
|
0.380 |
Biomarker
|
disease |
BEFREE |
Tissue microarray of breast cancer patients and immunohistochemical method were used to analyze the role of Trx-1 in breast cancer metastasis.
|
30396169 |
2018 |
|
Malignant neoplasm of breast
|
0.380 |
Biomarker
|
disease |
CTD_human |
Tissue microarray of breast cancer patients and immunohistochemical method were used to analyze the role of Trx-1 in breast cancer metastasis.
|
30396169 |
2018 |
|
Malignant neoplasm of breast
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Peroxiredoxin-1 (Prdx1), a member of the thioredoxin (Txn) system, is overexpressed and correlates with poor prognosis in pancreatic cancer patients and can suppress Kras signaling through redox-mediated inhibition of ERK and AKT in lung and breast cancer.
|
29190947 |
2017 |
|
Malignant neoplasm of breast
|
0.380 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to investigate the role of thioredoxin (Trx1) in the invasion and migration of breast cancer cells and to assess the strength of the association between high levels of Trx1 and thioredoxin reductase (TrxR1) expression with breast cancer patient survival.
|
26760912 |
2016 |