|
Poisoning by fluorouracil
|
0.300 |
Biomarker
|
disease |
ORPHANET |
|
|
|
|
Malignant neoplasm of stomach
|
0.400 |
Biomarker
|
disease |
BEFREE |
A randomized study was conducted to investigate schedule-dependent thymidylate synthase (TS) inhibition by 5-FU in 16 patients with gastric cancer who underwent surgical resection.
|
1451052 |
1992 |
|
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A randomized study was conducted to investigate schedule-dependent thymidylate synthase (TS) inhibition by 5-FU in 16 patients with gastric cancer who underwent surgical resection.
|
1451052 |
1992 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The amount of thymidylate synthase gene expression in tumor tissues was directly proportional to the content of thymidylate synthase protein.
|
1727369 |
1992 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Mutation(s) of the thymidylate synthase gene of human adenocarcinoma cells causes a thymidylate synthase-negative phenotype that can be attenuated by exogenous folates.
|
1732043 |
1992 |
|
Adenocarcinoma of colon
|
0.030 |
Biomarker
|
disease |
BEFREE |
Biological characterization of a human colon adenocarcinoma cell line deficient in thymidylate synthase (TS-) is described.
|
1732043 |
1992 |
|
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Activity of thymidylate synthetase, thymidine kinase and galactokinase in primary and xenografted human colorectal cancers in relation to their chromosomal patterns.
|
2004848 |
1991 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A clear correlation could be demonstrated between tumor types and enzyme activities: MT tumors had lower TS and higher TK and GalK activities than TT tumors.
|
2004848 |
1991 |
|
Adenocarcinoma of colon
|
0.030 |
Biomarker
|
disease |
BEFREE |
GC3/c1 human colon adenocarcinoma cells were treated with the mutagen ethyl methanesulfonate, and three clones deficient in thymidylate synthase (5,10-methylenetetrahydrofolate:dUMP C-methyltransferase, EC 2.1.1.
|
2537495 |
1989 |
|
Colonic Neoplasms
|
0.360 |
Biomarker
|
group |
BEFREE |
Thymidylate synthase as a determinant of 5-fluoro-2'-deoxyuridine response in human colonic tumor cell lines.
|
2971871 |
1988 |
|
Mental Retardation, X-Linked
|
0.010 |
Biomarker
|
disease |
BEFREE |
In order to obtain a model cell system suitable for studying the mechanism of expression of the fragile X site, interspecific somatic cell hybrids were constructed by cell fusion between human skin fibroblasts derived from a male patient with fragile X-linked mental retardation and thymidylate synthase-negative mouse mutant cells.
|
3935628 |
1985 |
|
Colorectal Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our result are based on preliminary data; however, they seem to support the hypothesis that a high TS level is a favourable prognostic factor in human colorectal carcinoma.
|
7645979 |
1995 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our data demonstrate that there is no association with age, sex, tumor site and tumor size; however, there is a relationship between TS levels and staging: in fact, the TS values are higher (P < 0.05) in Dukes-A tumors than in the others.
|
7645979 |
1995 |
|
Malignant neoplasm of colon and/or rectum
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thymidylate synthase level and DNA-ploidy pattern as possible prognostic factors in human colorectal cancer: a preliminary study.
|
7645979 |
1995 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil.
|
7763285 |
1995 |
|
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil.
|
7763285 |
1995 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this report we analyzed the mRNA expression of the resistance-related enzymes DNA topoisomerase II (Topo II), thymidylate synthase (TS), glutathione S-transferase-pi (GST-pi) and glutathione peroxidase (GP) in childhood acute lymphoblastic leukemia (ALL) and their correlation to the proliferative activity, determined by Ki-67.
|
7882295 |
1995 |
|
Stomach Neoplasms
|
0.370 |
AlteredExpression
|
group |
BEFREE |
Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors.
|
7882343 |
1995 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A semiquantitative technique for assessing TS RNA expression by PCR in breast cancer cell lines has been demonstrated.
|
8028610 |
1994 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A semiquantitative technique for assessing TS RNA expression by PCR in breast cancer cell lines has been demonstrated.
|
8028610 |
1994 |
|
Mammary Neoplasms
|
0.360 |
Biomarker
|
group |
BEFREE |
Therefore, a semiquantitative polymerase chain reaction (PCR) technique to measure TS RNA concentration in breast tumour cell lines has been developed with potential for measuring TS RNA levels in individual breast tumours.
|
8028610 |
1994 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Considering the two enzymes involved in pyrimidine metabolism, only TS had higher activity in glial tumours of high malignancy than in normal brain.
|
8054268 |
1994 |
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Considering the two enzymes involved in pyrimidine metabolism, only TS had higher activity in glial tumours of high malignancy than in normal brain.
|
8054268 |
1994 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Gene dosage and expression, and enzyme activity of thymidine kinase and thymidylate synthase in xenografted colorectal adenocarcinomas.
|
8112887 |
1994 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Such an interrelation was confirmed by the dosage of thymidylate synthase (TS) and thymidine kinase (TK) activities in a series of colorectal grafted tumors.
|
8112887 |
1994 |