|
Secondary malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Liver metastases showed absence of low TYMS expression, indicating insensitivity to pemetrexed-based regimen.
|
29948972 |
2019 |
|
Secondary malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thymidylate synthase: a predictive biomarker in resected colorectal liver metastases receiving 5-FU treatment.
|
29318904 |
2018 |
|
Secondary malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
High OPRT/TS and peritoneal metastasis (vs. liver metastasis) independently predicted responding.
|
27913881 |
2017 |
|
Secondary malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine if alterations of DNA copy number in genes involved in 5-FU metabolism-impacted clinical resistance to 5-FU-based chemotherapy, we assessed thymidylate synthetase (TYMS) and thymidine phosphorylase (TYMP) copy number in colorectal liver metastases.
|
20727737 |
2010 |
|
Secondary malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To address this issue, we studied TSER genotype, TS expression, and activity with specific polymerase chain reaction and activity assays (TS catalytic activity and FdUMP binding) in normal (liver, mucosa) and malignant (primary tumor and liver metastasis) tissues from 83 patients with CRC.
|
19632929 |
2009 |
|
Secondary malignant neoplasm of liver
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Liver metastases (n = 93) along with primary tumors (n = 48) were analyzed for K-Ras mutations (codons 12 and 13), p53 mutations (exons 4-9), p53 polymorphism (codon 72), thymidylate synthase (TS) polymorphism (28-bp repeats including G>C mutation), methylenetetrahydrofolate reductase polymorphism (677C>T, 1298A>C), thymidylate synthase (TS) activity, dihydropyrimidine dehydrogenase activity, folylpolyglutamate synthase activity, and p53 protein expression.
|
18676755 |
2008 |
|
Secondary malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we evaluated the correlation between sensitivity to 5-fluorouracil (5-FU) and the mRNA expression level of several 5-FU-related metabolic enzymes [thymidylate synthase, dihydropyrimidine dehydrogenase (DPD), thymidylate phosphorylase (TP), orotate phosphoribosyl transferase, and uridine phosphorylase] in primary colorectal cancer and synchronous liver metastases from ten patients to investigate how colorectal cancer acquires 5-FU resistance during liver metastases.
|
16525674 |
2006 |
|
Secondary malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
When matched tissue sets were compared on an individual basis, there was a significant correlation for TS mRNA expression between primary cancer and corresponding liver metastases (rs=0.52, p=0.0026).
|
16572420 |
2006 |
|
Secondary malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In both primary tumor and liver metastasis, the TS mRNA levels correlated significantly with the OPRT mRNA level (primary rS=0.83, P=0.00000081; liver metastasis rS=0.49, P=0.017), while the DPD mRNA level correlated significantly with the TP mRNA level rS=0.81, P=0.0000024; rS=0.63, P=0.0014; respectively).
|
15060742 |
2004 |
|
Secondary malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have found that mRNA levels of the E2F family of transcription factors correlates with TS message levels and are higher in lung metastases than in liver metastases of colorectal cancers.
|
12084458 |
2002 |
|
Secondary malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to evaluate three molecular genetic markers - p53, DCC (deleted in colonic cancer) and thymidylate synthase - in both the primary colorectal tumour and the resected hepatic metastases, and to determine their correlation, if any, with survival in patients with resected hepatic metastases from colorectal cancer.
|
12390383 |
2002 |
|
Secondary malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In contrast, TS mRNA expression in hepatic metastases was significantly lower than in primary tumors.
|
12450430 |
2001 |
|
Secondary malignant neoplasm of liver
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism was observed in the 5'-untranslated regions of the TS gene in hepatic metastases (n=6).
|
11686531 |
2001 |
|
Secondary malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Higher levels of thymidylate synthase gene expression are observed in pulmonary as compared with hepatic metastases of colorectal adenocarcinoma.
|
9552053 |
1998 |