|
Adenocarcinoma of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our experimental data establish that among NF-κB target genes, Uev1A-regulated <i>CXCL1</i> expression plays a critical role in colon cell invasion and metastasis, a notion supported by the colon adenocarcinoma survey.
|
29662619 |
2018 |
|
Adenocarcinoma of large intestine
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
No expression of Uev1A was detected in histologically normal human colonic mucosa, but its expression was detected in human colorectal adenocarcinoma, which was closely correlated with nuclear p65 levels, an indicator of NF-κB activation.
|
29662619 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibitor of DNA-Binding Protein 4 Suppresses Cancer Metastasis through the Regulation of Epithelial Mesenchymal Transition in Lung Adenocarcinoma.
|
31847356 |
2019 |
|
Alzheimer's Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The majority of patients with nonfluent variant (NFV) and logopenic variant (LV) PPA have underlying tauopathy of the frontotemporal lobar or Alzheimer disease type, respectively, while patients with the semantic variant (SV) have predominantly transactive response DNA binding protein 43-kDa pathology.
|
29946950 |
2018 |
|
Amyotrophic Lateral Sclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
A protein central to ALS is the nuclear RNA/DNA-binding protein, TDP-43.
|
30157956 |
2018 |
|
Amyotrophic Lateral Sclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Withania somnifera Reverses Transactive Response DNA Binding Protein 43 Proteinopathy in a Mouse Model of Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration.
|
27928708 |
2017 |
|
Amyotrophic Lateral Sclerosis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Dominant mutations in the RNA/DNA-binding protein TDP-43 have been linked to amyotrophic lateral sclerosis (ALS).
|
31067307 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
TDP-43 (transactive- response DNA binding protein) amazes structural biologist as its aberrant ubiquitinated cytosolic inclusions is largely involved in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
|
30315897 |
2019 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Previous reports have correlated the level of UEV1A expression with tumorigenesis; however, the detailed molecular events leading to tumors particularly breast cancer and metastasis are unclear.
|
25022892 |
2014 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The E3 ligase RNF8 acts in cooperation with the heterodimeric E2 enzyme Ubc13/Uev1a to generate ubiquitin conjugates at the sides of DNA double-strand breaks, and recent findings suggest RNF8 as a potential therapeutic target for the treatment of breast cancer.
|
27909234 |
2017 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Uev1A promotes cell survival under serum starvation stress through the AKT-FOXO1-BIM axis in breast cancer cells, which unveals a potential therapeutic target in the treatment of breast cancers.
|
31827405 |
2019 |
|
Carcinogenesis
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
This study is to investigate roles of different UEV1 splicing variants, and its close homolog MMS2, in promoting tumorigenesis and metastasis in breast cancer cells.
|
25022892 |
2014 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
BORIS (CTCFL) is a DNA binding protein which is involved in tumorigenesis.
|
30323717 |
2018 |
|
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
The genes upregulated in stroke patients were found to be involved in the MyD88-independent pathway and in UBE2V1-TRAF6 ubiquitin-mediated proteolysis.
|
23726813 |
2013 |
|
Childhood Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Uev1A facilitates osteosarcoma differentiation by promoting Smurf1-mediated Smad1 ubiquitination and degradation.
|
28771228 |
2017 |
|
Chronic rejection of renal transplant
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Three genes were significantly expressed between CAN and vascular AR: Pellino 2; IL 8 and UBE2V1.
|
19105982 |
2009 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In order to understand the roles of Uev1A in colon cancer progression, we experimentally manipulated the Uev1A level in HCT116 colon cancer cells and found that <i>UEV1A</i> overexpression alone is sufficient to promote invasion <i>in vitro</i> and metastasis <i>in vivo</i>.
|
29662619 |
2018 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results identify Uev1A as a potential therapeutic target in the treatment of metastatic colorectal cancers.
|
29662619 |
2018 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Ube2v1 promoted migration and invasion of CRC cells in vitro and tumor growth and metastasis of CRC cells in vivo.
|
30016968 |
2018 |
|
Congenital chromosomal disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Mutants dl312, dl314, hr1, and hr3 with mutations in region E1A of adenovirus type 5 were defective for the induction of cell cycle abnormalities detectable by flow cytometry, cell DNA replication, thymidine kinase production, and chromosome aberrations and did not synthesize the viral DNA-binding protein (E2A) in rat cells. dl311, a leaky E1A mutant, induced cell cycle effects at high multiplicity in only one of three experiments, and synthesized the DNA-binding protein. hr7 (E1B) gave a wild-type response in all tests. dl313 was also positive in all tests, although it induced fewer polyploid cells than did wild-type virus, probably because of the leftward extension of the dl313 E1B deletion into E1A. sub315 and sub316, with mutations which also span the E1A-E1B border, synthesized DNA-binding protein, but caused no cell cycle alterations detectable by flow cytometry in rat or mouse cells.
|
6823012 |
1983 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Transactive DNA Binding Protein 43 Rather Than Other Misfolded Proteins in the Brain is Associated with Islet Amyloid Polypeptide in Pancreas in Aged Subjects with Diabetes Mellitus.
|
28582864 |
2017 |
|
Diabetic Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
UBE2v1 mediates the formation of lysine 63-linked ubiquitin chains, a mechanism we previously showed as involved in DN kidney fibrosis.
|
31388051 |
2019 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Importantly, NSC697923 inhibits the proliferation and survival of ABC-DLBCL cells and GCB-DLBCL cells, suggesting the Ubc13-Uev1A may be crucial for DLBCL growth.
|
22791293 |
2012 |
|
Early infantile epileptic encephalopathy with suppression bursts
|
0.010 |
Biomarker
|
disease |
BEFREE |
The above findings identify UEV1A as a potential OS tumor suppression gene, and shed lights to future OS diagnosis and treatment.
|
28771228 |
2017 |
|
Enterovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Enteroviral Infection Leads to Transactive Response DNA-Binding Protein 43 Pathology in Vivo.
|
30273599 |
2018 |