UCHL1, ubiquitin C-terminal hydrolase L1, 7345

N. diseases: 260; N. variants: 7
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.040 AlteredExpression disease BEFREE Suppression of MITF activity by UCHL1 via protein degradation might aid in the development of new therapeutic approaches for melanoma or dyspigmentation disorders. 28392346 2017
CUI: C0025202
Disease: melanoma
melanoma 		0.040 Biomarker disease BEFREE Thus, the aberrant UCHL1 expression in melanoma cells is linked to dynamic changes in growth properties and signal transduction cascades suggesting that UCHL1 provides a novel marker and/or therapeutic target at least for a subset of melanoma patients. 23686552 2013
CUI: C0025202
Disease: melanoma
melanoma 		0.040 PosttranslationalModification disease BEFREE Cross-platform array screening identifies COL1A2, THBS1, TNFRSF10D and UCHL1 as genes frequently silenced by methylation in melanoma. 22028813 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.040 Biomarker disease LHGDN Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis. 18820707 2009