UCN, urocortin, 7349

N. diseases: 134; N. variants: 3
Disease: Depressed mood ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.020 AlteredExpression phenotype BEFREE In mice over-expressing neuronal CRF (an animal model for depression) the expression of urocortin 1 (Ucn1) in the non-preganglionic Edinger-Westphal nucleus (npEW) is strongly down-regulated. 18329817 2008
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.020 AlteredExpression phenotype BEFREE These data indicate that CRF receptor antagonists may be useful for the treatment of the disease states where CRF is elevated such as anxiety and depression, anorexia nervosa and stroke and that ligand inhibitors of CRF-BP may be used to elevate brain levels of 'free' urocortin and other CRF-related peptides. 9118350 1996