UCP1, uncoupling protein 1, 7350

N. diseases: 124; N. variants: 7
Disease: Atherosclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.040 AlteredExpression disease BEFREE These processes were correlated with the increased gene expression of Dio2 and Ucp-1, which represents brown adipose tissue (BAT) activation, in both WD-induced atherosclerosis and high-fat-induced obesity models. 31570705 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.040 Biomarker disease BEFREE Genetic deletion of the critical thermogenesis-dependent protein, uncoupling protein 1, completely abrogates the mirabegron-induced atherosclerosis. 31085638 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.040 Biomarker disease BEFREE In apoE null mice, a vascular disease model, diet-induced atherosclerosis was decreased in UCP animals. 18054318 2007
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.040 AlteredExpression disease BEFREE However, new findings show that expression of uncoupling protein 1 in aortic smooth muscle cells of mice increases reactive oxygen species, activates the renin-angiotensin system, elevates blood pressure, and worsens atherosclerosis. 16054094 2005